Species: Mu
Applications: WB, IHC, Dual ISH-IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB, Flow, IHC, B/N, CyTOF-ready
Host: Goat Polyclonal
Species: Hu
Applications: WB, Flow, IP
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Description
Human platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-alpha and PDGF receptor-beta. PDGF receptor-beta can only bind two specific PDGF isoforms, PDGF-beta and PDGF-delta (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
Human
Mouse
Human
|
| Product By Gene ID |
5159 |
| Alternate Names |
- beta-type platelet-derived growth factor receptor
- CD140 antigen-like family member B
- CD140b antigen
- CD140B
- CD140b
- EC 2.7.10
- EC 2.7.10.1
- JTK12
- PDGFR
- PDGFR1
- PDGF-R-beta
- platelet-derived growth factor receptor, beta polypeptide
|
Research Areas for PDGF R beta
Find related products by research area and learn more about each of the different research areas below.
Phospho-SpecificProtein Kinase
![Western Blot PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/PDGF_R_beta_AF1042_Western_Blot_17545.jpg)
![Immunohistochemistry PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/PDGF_R_beta_AF385_Immunohistochemistry_6811.jpg)
![Flow Cytometry PDGF R beta Antibody (PR7212) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab1263_human-pdgf-r-beta-mab-clone-pr7212-flow-cytometry-1712024194610..jpg)
![Sandwich ELISA PDGF R beta Antibody Pair [HRP]](http://images.novusbio.com/fullsize/PDGF-R-beta-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79481-img0001.jpg)
![ELISA PDGF R beta [Biotin]](http://images.novusbio.com/fullsize2/dyc385-2_human-total-pdgf-r-beta-duoset-ic-elisa-5-plate-elisa-1592020123158.jpg)
![ELISA PDGF R beta [p Tyr751] [Biotin]](http://images.novusbio.com/fullsize2/dyc3096-2_human-phospho-pdgf-r-beta-y751-duoset-ic-elisa-2-plate-elisa-159202015243.jpg)
![Binding Activity PDGF R beta [Biotin]](http://images.novusbio.com/fullsize/protein/avi10652_recombinant-human-pdgf-r-beta-fc-chimera-avi-tag-protein-cf-binding-activity-2411202091642.jpg)
![Immunohistochemistry PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/PDGF_R_beta_AF1042_Immunohistochemistry_6669.jpg)
![Immunohistochemistry PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1042_mouse-pdgf-r-beta-affinity-purified-polyclonal-ab-41202410481131.jpg)
![Immunocytochemistry/ Immunofluorescence PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1042_mouse-pdgf-r-beta-affinity-purified-polyclonal-ab-41202410484313.jpg)
![Immunohistochemistry PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1042_mouse-pdgf-r-beta-affinity-purified-polyclonal-ab-41202410484389.jpg)
![In-situ Hybridization PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af1042_mouse-pdgf-r-beta-affinity-purified-polyclonal-ab-in-situ-hybridization-235202421512..jpg)
![Neutralization PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/PDGF_R_beta_AF385_Block_Neutralize_970.jpg)
![Flow Cytometry PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af385_human-pdgf-r-beta-affinity-purified-polyclonal-ab-flow-cytometry-5102023103051..jpg)
![Flow Cytometry PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af385_human-pdgf-r-beta-affinity-purified-polyclonal-ab-flow-cytometry-5102023103745..jpg)
![Western Blot PDGF R beta Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af385_human-pdgf-r-beta-affinity-purified-polyclonal-ab-western-blot-264202483039..jpg)
![SDS-PAGE PDGF R beta [Biotin]](http://images.novusbio.com/fullsize/protein/avi10652_recombinant-human-pdgf-r-beta-fc-chimera-avi-tag-protein-cf-sds-page-2311202091810.jpg)