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PDGF R beta Antibody (PR7212) [DyLight 755]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IP
Clone
PR7212
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB1263U-100UG
Alexa Fluor 405
FAB1263V-100UG
Alexa Fluor 488
FAB1263G-100UG
Alexa Fluor 532
FAB1263X
Alexa Fluor 594
FAB1263T-100UG
Alexa Fluor 647
FAB1263R-100UG
Alexa Fluor 700
FAB1263N-100UG
Alexa Fluor 750
FAB1263S-100UG
Allophycocyanin
FAB1263A
Allophycocyanin/Cy7
FAB1263APCCY7
Biotin
FAB1263B
DyLight 350
FAB1263D
DyLight 405
FAB1263E
DyLight 488
FAB1263K
DyLight 550
FAB1263L
DyLight 594
FAB1263M
DyLight 650
FAB1263W
DyLight 680
FAB1263Y
Fluorescein
FAB1263F
HRP
FAB1263H
Janelia Fluor 525
FAB1263JF525
Janelia Fluor 549
FAB1263I
Janelia Fluor 635
FAB1263JF635
Janelia Fluor 646
FAB1263J
Janelia Fluor 669
FAB1263JF669
PE/Atto594
FAB1263PEATT594
PE/Cy5.5
FAB1263PECY55
PE/Cy7
FAB1263PECY7
PerCP (Peridinin-chlorophyll Protein Complex)
FAB1263C
Phycoerythrin
FAB1263P
Unconjugated
MAB1263
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB1263
Carrier Free
FAB1263A
Carrier Free
FAB1263C
Carrier Free
FAB1263F
Carrier Free
FAB1263P
Carrier Free
MAB1263
Carrier Free
MAB1263-SP
Carrier Free
FAB1263V-100UG
Carrier Free
FAB1263U-100UG
Carrier Free
FAB1263T-100UG
Carrier Free
FAB1263S-100UG
Carrier Free
FAB1263R-100UG
Carrier Free
FAB1263G-100UG
Carrier Free
FAB1263N-100UG
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PDGF R beta Antibody (PR7212) [DyLight 755] Summary

Immunogen
Human skin fibroblast membrane extracts
Specificity
Detects human PDGF R beta in Western blots. Specificity has been confirmed in binding studies using several different cell lines (1, 2) and by its ability to immunoprecipitate PDGF receptor beta ‑subunit complexed with 125I‑PDGF-BB (3). It does not recognize the PDGF receptor alpha ‑subunit. Detects the PDGF receptor beta ‑subunit of human and primate species (monkey and baboon) but not the rat or mouse receptors. Its ability to bind to receptors from other species has not been tested.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PDGFRB
Purity
Protein A or G purified from ascites
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from ascites

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PDGF R beta Antibody (PR7212) [DyLight 755]

  • beta-type platelet-derived growth factor receptor
  • CD140 antigen-like family member B
  • CD140b antigen
  • CD140b
  • EC 2.7.10
  • EC 2.7.10.1
  • JTK12
  • PDGF R beta
  • PDGFR
  • PDGFR1
  • PDGFRB
  • PDGF-R-beta
  • platelet-derived growth factor receptor, beta polypeptide

Background

Human platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Two major isoforms exist, PDGF receptor-alpha and PDGF receptor-beta. PDGF receptor-beta can only bind two specific PDGF isoforms, PDGF-beta and PDGF-delta (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PDGFRB