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HES6 Antibody

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Western Blot: HES6 Antibody [NBP2-87563] - WB Suggested Anti-HES6 Antibody Titration: 1.25ug/ml. Positive Control: Transfected 293T
Western Blot: HES6 Antibody [NBP2-87563] - WB Suggested Anti-HES6 Antibody Titration: 1.25ug/ml. Positive Control: Transfected 293T
Immunohistochemistry: HES6 Antibody [NBP2-87563] - Human Pancreas

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

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HES6 Antibody Summary

Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of human HES6. Peptide sequence: PPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRP The peptide sequence for this immunogen was taken from within the described region.
Clonality
Polyclonal
Host
Rabbit
Gene
HES6
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot 1.0 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein A purified

Alternate Names for HES6 Antibody

  • BHLHB41
  • bHLHb41Class B basic helix-loop-helix protein 41
  • bHLHc23
  • C-HAIRY1
  • hairy and enhancer of split 6 (Drosophila)
  • Hairy and enhancer of split 6
  • HES-6
  • transcription cofactor HES-6

Background

HES6 is a transcription cofactor that itself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumor and cancer cell lines, although these have not yet been elucidated fully.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HES6