HES6 Products

Description

HES6 is a transcription cofactor that itself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumor and cancer cell lines, although these have not yet been elucidated fully.

Bioinformatics

Entrez	55502 Human
Uniprot	NM_018645 Human NP_061115.2 Human
Product By Gene ID	55502
Alternate Names	BHLHB41 bHLHb41Class B basic helix-loop-helix protein 41 bHLHc23 C-HAIRY1 hairy and enhancer of split 6 (Drosophila) Hairy and enhancer of split 6 HES-6 transcription cofactor HES-6

Related HES6 Blog Posts

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Using the Hif-1 Alpha Antibody in Prostate Cancer Research The Hypoxia-inducible Factor 1 (HIF1) protein is a heterodimeric transcription factor which plays an important role in mammalian oxygen homeostasis in conditions of hypoxia, or low oxygen concentration. HIF-1 alpha antibody reagents are widely used in...    Read more.

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