HAX-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

HAX-1 (HCLS1-associated protein X-1; also HS1-binding protein1) is a 34‑35 kDa intracellular protein with structural similarity to Bcl-2 family proteins. It is ubiquitously expressed, and participates in a variety of cell-specific functions. HAX‑1 blocks cardiomyocyte apoptosis via caspase‑9 inhibition, downregulates conjugated bile acid secretion via BSEP binding, and via PKD2, transmitts integrin signals to the ER. Human HAX-1 is 279 amino acids (aa) in length and contains two Bcl-2 homology regions (aa 37‑56 and 74‑89), a PEST domain (aa 104‑117) and a potential transmembrane segment (aa 261‑279). HS-1 is found mostly in the mitochondria. HAX-1 is also cleaved by caspase-3 at Asp127. Over aa 2‑261, human HAX-1 shares 81% aa identity with mouse HAX-1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using AF5458	Applications	Species
Sharanya Chatterjee, Sujinna Lekmeechai, Nicolas Constantinou, Ewa A. Grzybowska, Zuzanna Kozik, Jyoti S. Choudhary et al. The type III secretion system effector EspO of enterohaemorrhagic Escherichia coli inhibits apoptosis through an interaction with HAX ‐1 Cellular Microbiology 9/1/2021 [PMID: 34021690]
Pedersen K, Canals F, Prat A, Tabernero J, Arribas J PELO negatively regulates HER receptor signalling and metastasis. Oncogene, 2013-02-25;33(9):1190-7. 2013-02-25 [PMID: 23435426] (Western Blot, Human)	Western Blot	Human

Array AF5458

• HAX-1 Antibodies
• HAX-1 Lysates
• HAX-1 Proteins