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GDF-5/BMP-14 Antibody

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Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)
Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)
Immunohistochemistry-Paraffin: GDF-5/BMP-14 Antibody [NBP1-88575] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells.
Western Blot: GDF-5/BMP-14 Antibody [NBP1-88575] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-236

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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GDF-5/BMP-14 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: RYVFDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDL
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GDF5
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot 0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
GDF-5/BMP-14 Protein (NBP1-88575PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for GDF-5/BMP-14 Antibody

  • BMP14
  • BMP-14
  • Cartilage-derived morphogenetic protein 1
  • cartilage-derived morphogenetic protein-1
  • CDMP-1
  • CDMP1LAP4
  • GDF5
  • GDF-5
  • growth differentiation factor 5
  • growth/differentiation factor 5
  • OS5
  • radotermin
  • SYNS2

Background

The GDF5 gene is involved in skeletal development through bone and cartilage formation. This gene encodes for a 501 amino acid long, 55 kDA protein that is part of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily which is known to regulate cell growth and differentiation in embryotic and adult tissues. The GDF5 gene is involved in paxillian interactions, mitochondrial apoptosis, the cytokine-cytokine receptor interaction, and the TGF-beta signaling pathway through interacting with other genes such as BMPR1A, BMPR1B, BMPR2, HTRA1, and CHRDL2. The GDF5 gene has been associated to chondrodysplasia, synostosis, periostitis, short stature, cushing's symphalangism, brachydactyly and ankylosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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GDF-5/BMP-14
Antibody
NBP1-88575
GDF-5/BMP-14 Antibody
Species: Hu, Mu, Rt
Applications: WB, IHC

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Bioinformatics

Gene Symbol GDF5