CXCL12/SDF-1 Antibody (79014) [Unconjugated]

Images

 
Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (Catalog # 350-NS) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR4 in a dose-dependent manner (orange line). Chemotaxis elicited ...read more
Enumeration of bone marrow and blood Lin−/Sca1+ cell numbers following stroke and SDF1-A Antibody.(A) Twenty-four hour post stroke+SDF1-A antibody mice show a marked increase in the number of Lin−/Sca1+ cells ...read more
Administration of Lin−/Sca1+ cells post stroke.A. Administration of Lin−/Sca1+ cells post stroke significantly reduced infarct volume at 24 hours post stroke (*P<0.05). B. Administration of the Lin−/Sca1+ cells ...read more
Enumeration of bone marrow and blood Lin−/Sca1+ cell numbers following stroke and SDF1-A Antibody.(A) Twenty-four hour post stroke+SDF1-A antibody mice show a marked increase in the number of Lin−/Sca1+ cells ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications B/N
Clone
79014
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

CXCL12/SDF-1 Antibody (79014) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human CXCL12/SDF‑1 alpha
Lys22-Lys89
Accession # Q6ICW0
Specificity
Detects human and mouse CXCL12/SDF‑1 alpha and human CXCL12/SDF‑1 beta .
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CXCL12
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Neutralization
Publications
Read Publications using
MAB310 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL12/SDF-1 Antibody (79014) [Unconjugated]

  • chemokine (C-X-C motif) ligand 12
  • C-X-C motif chemokine 12
  • CXCL12
  • hIRH
  • hSDF-1
  • Intercrine reduced in hepatomas
  • IRH
  • PBSF
  • PBSFSDF-1a
  • Pre-B cell growth-stimulating factor
  • SCYB12
  • SDF1
  • SDF-1
  • SDF1A
  • SDF1B
  • SDF1SDF-1b
  • stromal cell-derived factor 1
  • TLSF
  • TLSF-a
  • TLSF-b
  • TPAR1

Background

CXCL12, also known as SDF-1 (stromal cell-derived factor 1) and PBSF (Pre-B cell growth stimulatory factor), is a member of the CXC chemokine superfamily. Two alternatively spliced mRNAs encode CXCL12 alpha (89 aa residues) and CXCL12 beta (93 aa residues) that differ by the addition of 4 amino acids at the carboxy-terminus. Human and mouse CXCL12 are highly conserved. Mature human and mouse CXCL12 differ only by 1 amino acid.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCL12/SDF-1 Antibody (MAB310)(65)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Canine, Transgenic Mouse.

We have publications tested in 11 applications: Bioassay, ELISA Capture, ELISA Development (Capture), Flow Cytometry, Functional Assay, IHC, IHC-P, Immunoprecipitation, In Vivo, Neutralization, Western Blot.


Filter By Application
Bioassay
(2)
ELISA Capture
(1)
ELISA Development (Capture)
(1)
Flow Cytometry
(3)
Functional Assay
(2)
IHC
(4)
IHC-P
(1)
Immunoprecipitation
(1)
In Vivo
(1)
Neutralization
(32)
Western Blot
(3)
All Applications
Filter By Species
Human
(16)
Mouse
(27)
Rat
(2)
Canine
(1)
Transgenic Mouse
(1)
All Species
Showing Publications 1 - 10 of 65. Show All 65 Publications.
Publications using MAB310 Applications Species
Pu, T;Wang, J;Wei, J;Zeng, A;Zhang, J;Chen, J;Yin, L;Li, J;Lin, TP;Melamed, J;Corey, E;Gao, AC;Wu, BJ; Stromal-derived MAOB promotes prostate cancer growth and progression Science advances 2024-02-09 [PMID: 38335292] (Neutralization, Human) Neutralization Human
Chen, J;Bai, Y;Xue, K;Li, Z;Zhu, Z;Li, Q;Yu, C;Li, B;Shen, S;Qiao, P;Li, C;Luo, Y;Qiao, H;Dang, E;Yin, W;Gudjonsson, JE;Wang, G;Shao, S; CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients Nature communications 9/22/2023 [PMID: 37736772]
Li, Y;Xue, M;Deng, X;Dong, L;Nguyen, LXT;Ren, L;Han, L;Li, C;Xue, J;Zhao, Z;Li, W;Qing, Y;Shen, C;Tan, B;Chen, Z;Leung, K;Wang, K;Swaminathan, S;Li, L;Wunderlich, M;Mulloy, JC;Li, X;Chen, H;Zhang, B;Horne, D;Rosen, ST;Marcucci, G;Xu, M;Li, Z;Wei, M;Tian, J;Shen, B;Su, R;Chen, J; TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal Cell stem cell 2023-08-03 [PMID: 37541212] (Neutralization, Transgenic Mouse) Neutralization Transgenic Mouse
Pajulas, A;Fu, Y;Cheung, CCL;Chu, M;Cannon, A;Alakhras, N;Zhang, J;Ulrich, BJ;Nelson, AS;Zhou, B;Kaplan, MH; Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation Mucosal immunology 2023-05-10 [PMID: 37172907] (Bioassay, Mouse) Bioassay Mouse
JM Houthuijze, R de Bruijn, E van der Bu, AP Drenth, E Wientjens, T Filipovic, E Bullock, CS Brambillas, EM Pulver, M Nieuwland, I de Rink, F van Diepen, S Klarenbeek, R Kerkhoven, VG Brunton, CLGJ Scheele, MC Boelens, J Jonkers CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer Nature Communications, 2023-01-12;14(1):183. 2023-01-12 [PMID: 36635273] (Neutralization, Mouse) Neutralization Mouse
KTP Nguyen, B Volkman, D Dréau, IV Nesmelova A new obligate CXCL4-CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms Scientific Reports, 2022-10-13;12(1):17204. 10/13/2022 [PMID: 36229490]
Y Xu, Z Wei, M Feng, D Zhu, S Mei, Z Wu, Q Feng, W Chang, M Ji, C Liu, Y Zhu, L Shen, F Yang, Y Chen, Y Feng, J Xu, D Zhu Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers Cell Reports, 2022-08-30;40(9):111295. 2022-08-30 [PMID: 36044847] (In Vivo, Mouse) In Vivo Mouse
A Jarade, Z Garcia, S Marie, A Demera, I Prinz, P Bousso, JP Di Santo, N Serafini Inflammation triggers ILC3 patrolling of the intestinal barrier Nature Immunology, 2022-08-23;0(0):. 8/23/2022 [PMID: 35999393]
Chun‐Yi Ng, Khang Leng Lee, Mark Dhinesh Muthiah, Kan Xing Wu, Florence Wen Jing Chioh, Konstanze Tan et al. Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease EMBO reports 6/7/2022 [PMID: 35403791]
SF Mause, E Ritzel, A Deck, F Vogt, EA Liehn Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis International Journal of Molecular Sciences, 2022-01-14;23(2):. 2022-01-14 [PMID: 35055054] (Neutralization, Human) Neutralization Human
Show All 65 Publications.

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Bioinformatics

Gene Symbol CXCL12
Uniprot