DPPIV/CD26 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

DPPIV/CD26 (EC 3.4.14.5) is a serine exopeptidase that releases Xaa-Pro dipeptides from the N-terminus of oligo- and polypeptides. It is a type II membrane protein consisting of a short cytoplasmic tail, a transmembrane domain, and a long extracellular domain. The extracellular domain contains glycosylation sites, a cysteine-rich region and the catalytic active site (Ser, Asp and His charge relay system). The amino acid sequence of the mouse DPPIV/CD26 extracellular domain is 84% and 91% identical to the human and rat counterparts, respectively. In the native state, DPPIV/CD26 is present as a noncovalently linked homodimer on the cell surface of a variety of cell types. The soluble form is also detectable in human serum and other body fluids, the levels of which may have clinical significance in patients with cancer, liver and kidney diseases, and depression.

DPPIV/CD26 plays an important role in many biological and pathological processes. It functions as T cell-activating molecule (THAM). It serves as a cofactor for entry of HIV in CD4⁺ cells. It binds adenosine deaminase, the deficiency of which causes severe combined immunodeficiency disease in humans. It cleaves chemokines such as stromal-cell-derived factor 1 alpha and macrophage-derived chemokine. It degrades peptide hormones such as glucagon. It truncates procalcitonin, a marker for systemic bacterial infections with elevated levels detected in patients with thermal injury, sepsis and severe infection, and in children with bacterial meningitis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 7 confirmed species: Human, Mouse, Rat, Bat, Camelid, Ferret, Primate.

We have publications tested in 9 applications: Blocking, Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 10 of 55. Show All 55 Publications. Collapse Publications.

Publications using AF1180	Applications	Species
Mayer C, Nehring S, K�cken M et al. Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease EMBO reports 2023-09-06 [PMID: 37522754]
Jing Chen, Xinglou Yang, Haorui Si, Qianchun Gong, Tengcheng Que, Jing Li et al. A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry Cell 2023-02-16 [PMID: 36803605]
KMC Klee, MW Hess, M Lohmüller, S Herzog, K Pfaller, T Müller, GF Vogel, LA Huber A CRISPR screen in intestinal epithelial cells identifies novel factors for polarity and apical transport Elife, 2023-01-20;12(0):. 2023-01-20 [PMID: 36661306] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
J Beumer, J Bauzá-Mart, TS Veth, V Geurts, C Boot, H Gilliam-Vi, SS Poulsen, FK Knop, W Wu, H Clevers Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models Proceedings of the National Academy of Sciences of the United States of America, 2022-11-07;119(46):e2212057119. 2022-11-07 [PMID: 36343264] (IHC, Human)	IHC	Human
Måns Kadefors, Frida Berlin, Marie Wildt, Göran Dellgren, Sara Rolandsson Enes, Anders Aspberg et al. Dipeptidyl peptidase 4 expression is not associated with an activated fibroblast phenotype in idiopathic pulmonary fibrosis Frontiers in Pharmacology 2022-08-31 [PMID: 36120350]
J.J. Patten, Patrick T. Keiser, Deisy Morselli-Gysi, Giulia Menichetti, Hiroyuki Mori, Callie J. Donahue et al. Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization iScience 2022-09-16 [PMID: 35992305]
T Turunen, M Magris, M Malinen, J Kekäläinen Seminal-Plasma-Mediated Effects on Sperm Performance in Humans Cells, 2022-07-08;11(14):. 2022-07-08 [PMID: 35883590] (Western Blot, Human)	Western Blot	Human
Kun Li, Christine Wohlford-Lenane, Jennifer A. Bartlett, Paul B. McCray Inter-individual Variation in Receptor Expression Influences MERS-CoV Infection and Immune Responses in Airway Epithelia Frontiers in Public Health 2022-01-04 [PMID: 35059374]
C Nadolny, X Zhang, Q Chen, SF Hashmi, W Ali, C Hemme, N Ahsan, Y Chen, R Deng Dysregulation and activities of ubiquitin specific peptidase 2b in the pathogenesis of hepatocellular carcinoma American journal of cancer research, 2021-10-15;11(10):4746-4767. 2021-10-15 [PMID: 34765291] (Western Blot, Human)	Western Blot	Human
Joep Beumer, Maarten H. Geurts, Mart M. Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart et al. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses Nature Communications 2021-09-17 [PMID: 34535662]
Y Ogawa, Y Akimoto, M Ikemoto, Y Goto, A Ishikawa, S Ohta, Y Takase, H Kawakami, M Tsujimoto, R Yanoshita Stability of human salivary extracellular vesicles containing dipeptidyl peptidase IV under simulated gastrointestinal tract conditions Biochemistry and Biophysics Reports, 2021-06-03;27(0):101034. 2021-06-03 [PMID: 34141904] (Western Blot, Human)	Western Blot	Human
S Kamada, T Namekawa, K Ikeda, T Suzuki, M Kagawa, H Takeshita, A Yano, K Okamoto, T Ichikawa, K Horie-Inou, S Kawakami, S Inoue Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma Oncogene, 2021-05-10;0(0):. 2021-05-10 [PMID: 33972682] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Michael W. Hess, Iris M. Krainer, Przemyslaw A. Filipek, Barbara Witting, Karin Gutleben, Ilja Vietor et al. Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations Journal of Clinical Medicine 2021-04-28 [PMID: 33924896]
Coate KC, Cha J, Shrestha S et al. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in beta Cells Int J Mol Sci 11/12/2020 [PMID: 33207245]
S Takagi, M Hirokawa, K Nagashima, M Higuchi, K Kadota, R Ishikawa, M Sato, A Miyauchi, Y Miyake, R Haba Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma: a useful marker for capsular invasion Endocr. J., 2020-09-02;0(0):. 2020-09-02 [PMID: 32879160] (IHC, Human)	IHC	Human
TJ Kolanowski, N Rozwadowsk, A Zimna, M Nowaczyk, M Siatkowski, W ?ab?d?, E Wiland, J Gapi?ski, S Jurga, M Kurpisz Chromatin and transcriptome changes in human myoblasts show spatio-temporal correlations and demonstrate DPP4 inhibition in differentiated myotubes Sci Rep, 2020-08-31;10(1):14336. 2020-08-31 [PMID: 32868771] (Western Blot, Human)	Western Blot	Human
Christal A. Worthen, Yilei Cui, Jeffrey S. Orringer, Timothy M. Johnson, John J. Voorhees, Gary J. Fisher CD26 Identifies a Subpopulation of Fibroblasts that Produce the Majority of Collagen during Wound Healing in Human Skin Journal of Investigative Dermatology 2020-12-01 [PMID: 32407715]
W Peng, D Rao, M Zhang, Y Shi, J Wu, G Nie, Q Xia Teneligliptin prevents doxorubicin-induced inflammation and apoptosis in H9c2 cells Arch. Biochem. Biophys., 2019-12-24;0(0):108238. 2019-12-24 [PMID: 31881187] (Western Blot, Rat)	Western Blot	Rat
Menachery V, Dinnon K, Yount B, McAnarney E, Gralinski L, Hale A, Graham R, Scobey T, Anthony S, Wang L, Graham B, Randell S, Lipkin W, Baric R Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection. J Virol, 2020-02-14;94(5):. 2020-02-14 [PMID: 31801868] (Human)		Human
YN Chen, HC Hsu, SW Wang, HC Lien, HT Lu, SK Peng Entry of Scotophilus Bat Coronavirus-512 and Severe Acute Respiratory Syndrome Coronavirus in Human and Multiple Animal Cells Pathogens, 2019-11-22;8(4):. 2019-11-22 [PMID: 31766704] (ICC, Human)	ICC	Human
N Schmid, F Flenkentha, JB Stöckl, KG Dietrich, FM Köhn, JU Schwarzer, L Kunz, M Luckner, G Wanner, GJ Arnold, T Fröhlich, A Mayerhofer Insights into replicative senescence of human testicular peritubular cells Sci Rep, 2019-10-21;9(1):15052. 2019-10-21 [PMID: 31636313] (IHC, Human)	IHC	Human
Hayashi M, Madokoro H, Yamada K et al. Novel Antibody-Drug Conjugate with Anti-CD26 Humanized Monoclonal Antibody and Transcription Factor IIH (TFIIH) Inhibitor, Triptolide, Inhibits Tumor Growth via Impairing mRNA Synthesis Cancers (Basel) 8/8/2019 [PMID: 31398954]
Vazquez-Iglesias L, Barcia-Castro L, Rodriguez-Quiroga M et al. Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+ cancer stem cells subsets Biol Open 7/19/2019 [PMID: 31285270]
R Hatano, T Yamada, H Madokoro, H Otsuka, E Komiya, T Itoh, Y Narita, S Iwata, H Yamazaki, S Matsuoka, NH Dang, K Ohnuma, C Morimoto Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens PLoS ONE, 2019-06-13;14(6):e0218330. 2019-06-13 [PMID: 31194830] (Flow Cytometry, Human)	Flow Cytometry	Human
Naoko Iwata-Yoshikawa, Tadashi Okamura, Yukiko Shimizu, Osamu Kotani, Hironori Sato, Hanako Sekimukai et al. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus Journal of Virology 2019-03-15 [PMID: 30626685]
AS Cockrell, JC Johnson, IN Moore, DX Liu, KW Bock, MG Douglas, RL Graham, J Solomon, L Torzewski, C Bartos, R Hart, RS Baric, RF Johnson A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques Sci Rep, 2018-07-16;8(1):10727. 2018-07-16 [PMID: 30013082] (IHC, Primate)	IHC	Primate
AK Haverkamp, A Lehmbecker, I Spitzbarth, W Widagdo, BL Haagmans, J Segalés, J Vergara-Al, A Bensaid, JMA van den Br, ADME Osterhaus, W Baumgärtne Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4 Sci Rep, 2018-06-27;8(1):9778. 2018-06-27 [PMID: 29950581] (ICC, Camelid)	ICC	Camelid
H Chu, CM Chan, X Zhang, Y Wang, S Yuan, J Zhou, RK Au-Yeung, KH Sze, D Yang, H Shuai, Y Hou, C Li, X Zhao, VK Poon, SP Leung, ML Yeung, J Yan, G Lu, DY Jin, GF Gao, JF Chan, KY Yuen Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells J. Biol. Chem., 2018-06-10;0(0):. 2018-06-10 [PMID: 29887526] (IHC-P, Neutralization, Western Blot, Human)	IHC-P, Neutralization, Western Blot	Human
CM Luo, N Wang, XL Yang, HZ Liu, W Zhang, B Li, B Hu, C Peng, QB Geng, GJ Zhu, F Li, ZL Shi Discovery of novel bat coronaviruses in south China that use the same receptor as MERS coronavirus J. Virol., 2018-06-13;0(0):. 2018-06-13 [PMID: 29669833] (Neutralization, Bat)	Neutralization	Bat
Leen J M Seys, W Widagdo, Fien M Verhamme, Alex Kleinjan, Wim Janssens, Guy F Joos et al. DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients Clinical Infectious Diseases 2018-01-06 [PMID: 29020176]
W Li, RJG Hulswit, I Widjaja, VS Raj, R McBride, W Peng, W Widagdo, MA Tortorici, B van Dieren, Y Lang, JWM van Lent, JC Paulson, CAM de Haan, RJ de Groot, FJM van Kuppev, BL Haagmans, BJ Bosch Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein Proc. Natl. Acad. Sci. U.S.A., 2017-09-18;0(0):. 2017-09-18 [PMID: 28923942] (Flow Cytometry, Human)	Flow Cytometry	Human
W Mah, G Jiang, D Olver, C Gallant-Be, C Wiebe, DA Hart, L Koivisto, H Larjava, L Häkkinen Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts Am. J. Pathol., 2017-06-20;0(0):. 2017-06-20 [PMID: 28641076] (IHC, Human)	IHC	Human
E Angevin, N Isambert, V Trillet-Le, B You, J Alexandre, G Zalcman, P Vielh, F Farace, F Valleix, T Podoll, Y Kuramochi, I Miyashita, O Hosono, NH Dang, K Ohnuma, T Yamada, Y Kaneko, C Morimoto First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers Br. J. Cancer, 2017-03-14;116(9):1126-1134. 2017-03-14 [PMID: 28291776] (IHC, Human)	IHC	Human
Mutsumi Hayashi, Hiroko Madokoro, Koji Yamada, Hiroko Nishida, Chikao Morimoto, Michiie Sakamoto et al. A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition Cancer Cell International 2016-12-01 [PMID: 27134571]
Dominika Wolczyk, Magdalena Zaremba-Czogalla, Anita Hryniewicz-Jankowska, Renata Tabola, Krzysztof Grabowski, Aleksander F. Sikorski et al. TNF-alpha promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts Cell Oncol (Dordr) 2016-08-01 [PMID: 27042827]
Neeltje van Doremalen, Kerri L. Miazgowicz, Vincent J. Munster Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus Journal of Virology 2016-06-01 [PMID: 27030263]
Lessard J, Pelletier M, Biertho L, Biron S, Marceau S, Hould F, Lebel S, Moustarah F, Lescelleur O, Marceau P, Tchernof A Characterization of dedifferentiating human mature adipocytes from the visceral and subcutaneous fat compartments: fibroblast-activation protein alpha and dipeptidyl peptidase 4 as major components of matrix remodeling. PLoS ONE, 2015-03-27;10(3):e0122065. 2015-03-27 [PMID: 25816202] (Western Blot, Human)	Western Blot	Human
Ohnuma K, Hatano R, Aune T, Otsuka H, Iwata S, Dang N, Yamada T, Morimoto C Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes. J Immunol, 2015-03-18;194(8):3697-712. 2015-03-18 [PMID: 25786689] (IHC-P, Mouse)	IHC-P	Mouse
Peck K, Cockrell A, Yount B, Scobey T, Baric R, Heise M Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection. J Virol, 2015-02-04;89(8):4696-9. 2015-02-04 [PMID: 25653445] (IHC, Human)	IHC	Human
Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus. J Virol, 2015-01-21;89(7):3859-69. 2015-01-21 [PMID: 25609809] (Blocking, Human)	Blocking	Human
Agrawal A, Garron T, Tao X, Peng B, Wakamiya M, Chan T, Couch R, Tseng C Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease. J Virol, 2015-01-14;89(7):3659-70. 2015-01-14 [PMID: 25589660] (IHC-P, Western Blot, Human)	IHC-P, Western Blot	Human
Cai Y, Yu S, Postnikova E, Mazur S, Bernbaum J, Burk R, Zhang T, Radoshitzky S, Muller M, Jordan I, Bollinger L, Hensley L, Jahrling P, Kuhn J CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection. PLoS ONE, 2014-11-19;9(11):e112060. 2014-11-19 [PMID: 25409519] (Neutralization, Human)	Neutralization	Human
Weng , Matthias, Natarajan , Karthick, Scholz , Diana, Ivanova , Violeta, Sachinidis , Agapios, Hengstler , Jan G, Waldmann , Tanja, Leist , Marcel Lineage-specific regulation of epigenetic modifier genes in human liver and brain. PLoS ONE, 2014-07-23;9(7):e102035. 2014-07-23 [PMID: 25054330] (ICC, Human)	ICC	Human
Yamamoto , J, Ohnuma , K, Hatano , R, Okamoto , T, Komiya , E, Yamazaki , H, Iwata , S, Dang , N H, Aoe , K, Kishimoto , T, Yamada , T, Morimoto , C Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma. Br J Cancer, 2014-04-17;110(9):2232-45. 2014-04-17 [PMID: 24743707] (ICC, IHC, Immunoprecipitation, Western Blot, Human)	ICC, IHC, Immunoprecipitation, Western Blot	Human
Jianyong Qiu, Jianyong Zhu, XiaoDong Guo, Zhiyan Li, Nianxin Xia, Yingxiang Yang et al. Prognostic significance of the combined expression of neutral endopeptidase and dipeptidyl peptidase IV in intrahepatic cholangiocarcinoma patients after surgery resection OncoTargets and Therapy 2014-02-27 [PMID: 24570591]
Eckerle I, Muller M, Kallies S, Gotthardt D, Drosten C In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J, 2013-12-23;10(0):359. 2013-12-23 [PMID: 24364985] (IHC, Human)	IHC	Human
Raj , V Stalin, Smits , Saskia L, Provacia , Lisette, van den Brand , Judith M, Wiersma , Lidewij, Ouwendijk , Werner J, Bestebroer , Theo M, Spronken , Monique, van Amerongen , Geert, Rottier , Peter J, Fouchier , Ron A M, Bosch , Berend J, Osterhaus , Albert D, Haagmans , Bart L Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus. J Virol, 2013-11-20;88(3):1834-8. 2013-11-20 [PMID: 24257613] (Flow Cytometry, Ferret, Human)	Flow Cytometry	Ferret, Human
Havre , Pamela A, Dang , Long H, Ohnuma , Kei, Iwata , Satoshi, Morimoto , Chikao, Dang , Nam H CD26 expression on T-anaplastic large cell lymphoma (ALCL) line Karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion. BMC Cancer, 2013-11-01;13(0):517. 2013-11-01 [PMID: 24180670] (Western Blot, Human)	Western Blot	Human
Kohji Yamada, Mutsumi Hayashi, Hiroko Madokoro, Hiroko Nishida, Wenlin Du, Kei Ohnuma et al. Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription PLoS ONE 2013-04-29 [PMID: 23638030]
Frédérique Souazé, Chantal Bou-Hanna, Christine Kandel, François Leclair, Julie Devallière, Béatrice Charreau et al. Differential Roles of Hath1, MUC2 and P27Kip1 in Relation with Gamma-Secretase Inhibition in Human Colonic Carcinomas: A Translational Study PLoS ONE 2013-02-11 [PMID: 23409082]
Ai-li Sun, Jing-ti Deng, Guang-ju Guan, Shi-hong Chen, Yuan-tao Liu, Jing Cheng et al. Dipeptidyl peptidase-IV is a potential molecular biomarker in diabetic kidney disease Diabetes and Vascular Disease Research 2012-10-01 [PMID: 22388283]
Amatya VJ, Takeshima Y, Kushitani K et al. Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines. Oncol Rep. 12/1/2011 [PMID: 21894438]
Masako Abe, Pamela A Havre, Yasuyo Urasaki, Kei Ohnuma, Chikao Morimoto, Long H Dang et al. Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines BMC Cancer 2011-12-01 [PMID: 21284881]
Yamaguchi U, Nakayama R, Honda K, Ichikawa H, Hasegawa T, Shitashige M, Ono M, Shoji A, Sakuma T, Kuwabara H, Shimada Y, Sasako M, Shimoda T, Kawai A, Hirohashi S, Yamada T Distinct gene expression-defined classes of gastrointestinal stromal tumor. J. Clin. Oncol., 2008-09-01;26(25):4100-8. 2008-09-01 [PMID: 18757323] (IHC-P, Human)	IHC-P	Human
Shin JW, Jurisic G, Detmar M Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function. Exp. Cell Res., 2008-08-03;314(16):3048-56. 2008-08-03 [PMID: 18708048] (IHC-Fr, Western Blot, Human)	IHC-Fr, Western Blot	Human
Show All 55 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Sam Connell	IHC-Fr	Human	02/22/2019	View Summary Application Immunohistochemistry-Frozen Sample Tested Frozen human skin sections Species Human Lot JOQ0218011
	4 reviewed by: Verified Customer	IHC-P	Human	01/05/2015	View Summary Application Immunohistochemistry-Paraffin Sample Tested See PMID 23638030 Species Human

Array AF1180

• DPPIV/CD26 Antibodies
• DPPIV/CD26 ELISA Kits
• DPPIV/CD26 Kits
• DPPIV/CD26 Lysate
• DPPIV/CD26 Proteins
• DPPIV/CD26 ELISAs
• DPPIV/CD26 Proteins and Enzymes