Calnexin Antibody (3H4A7)

Calnexin, also referred to as IP90, p88 and p90, is an ~90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatability complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP 78 and GRP 94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids). These features distinguish calnexin from soluble ER chaperones that cannot interact with the transmembrane and cytosolic domains of integral membrane proteins. The amino acid sequence of calnexin is highly conserved among species, and shares regions of high sequence homology with calreticulin.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-47546	Applications	Species
Arachchige SP, Henke W, Pramanik A et al. Analysis of Select HSV-1 Proteins for Restriction of Human Immunodeficiency Virus Type 1: The HSV-1 gM Protein Potently Restricts HIV-1 by Preventing the Intracellular Transport and Processing of Env gp160 J. Virol. 2017-11-01 [PMID: 29093081] (Human)		Human
Kulbay M, Johnson B, Ricaud G et al. DFF40 translocates to the mitochondria during apoptosis and regulates mitochondrial integrity and function Research Square 2021-02-10
Kim S, Lee K, Choi YS et al. Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development Cell reports 2022-08-09 [PMID: 35947956] (WB) Details: Supplementary Figure S5.	WB

Array NBP1-47546

• Calnexin Antibodies
• Calnexin ELISA Kits
• Calnexin Lysates
• Calnexin Proteins