ERp57/PDIA3 Antibody

ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glucosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NBP1-84796	Applications	Species
Bechor E, Dahan I, Fradin T et al. The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67phox. Front Chem 2015-01-01 [PMID: 25699251] (WB, Human)	WB	Human
Feng H, Li X, Chan V, Chen WN. Proteomics Based Identification of Cell Migration Related Proteins in HBV Expressing HepG2 Cells. PLoS One 2014-01-01 [PMID: 24763314] (WB)	WB
Logan CV, Szabadkai G, Sharpe JA et al. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet 2014-02-01 [PMID: 24336167]
Racape M, Duong Van Huyen JP, Danger R et al. The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. PLoS One 2011-01-01 [PMID: 21603654]

Array NBP1-84796

• ERp57/PDIA3 Antibodies
• ERp57/PDIA3 ELISA Kits
• ERp57/PDIA3 Lysate
• ERp57/PDIA3 Proteins