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Calnexin Products

Antibodies
ELISA Kits
Human Calnexin ELISA Kit (Col ...
Human Calnexin ELISA Kit (Colorime...
NBP2-75816
Species: Hu
Applications: ELISA
Mouse Calnexin ELISA Kit (Col ...
Mouse Calnexin ELISA Kit (Colorime...
NBP2-75817
Species: Mu
Applications: ELISA
Rat Calnexin ELISA Kit (Color ...
Rat Calnexin ELISA Kit (Colorimetric)
NBP2-75818
Species: Rt
Applications: ELISA
Lysates
Calnexin Overexpression Lysat ...
Calnexin Overexpression Lysate
NBP2-11041
Species: Hu
Applications: WB
Calnexin Overexpression Lysat ...
Calnexin Overexpression Lysate
NBP2-10767
Species: Hu
Applications: WB
Proteins
Calnexin Antibody Blocking Pe ...
Calnexin Antibody Blocking Peptide
NB100-1965PEP
Species: Ca
Applications: AC
Calnexin Antibody Blocking Pe ...
Calnexin Antibody Blocking Peptide
NB100-1974PEP
Species: Rt
Applications: AC
Recombinant Human Calnexin Pr ...
Recombinant Human Calnexin Protein
NBP1-30235
Species: Hu
Applications: PAGE

Description

Calnexin, an abundant approx. 90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their Cterminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into mulit-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).

Bioinformatics

Entrez Mouse
Rat
Canine
Human
Uniprot Human
Human
Human
Canine
Human
Rat
Product By Gene ID 821
Alternate Names
  • calnexin
  • CNX
  • IP90FLJ26570
  • Major histocompatibility complex class I antigen-binding protein p88
  • p90
  • P90

Research Areas for Calnexin

Find related products by research area and learn more about each of the different research areas below.

ER Markers
Neuroscience
Phospho-Specific
Sensory Systems
Unfolded Protein Response
Vision

Related Calnexin Blog Posts

Check out the latest blog posts on Calnexin.
Calnexin - an ER chaperone that folds the cell's glycoproteins
Calnexin is an abundant 90kDa chaperone protein that resides in the membrane of the endoplasmic reticulum. Calnexin and the related calreticulin protein function together to ensure the proper folding of glycoproteins. By binding to partially folded...    Read more.
Read more Calnexin related blogs.