Novus Biologicals products are now on bio-techne.com

Caldesmon/CALD1 Antibody (CALD1/1424R) [HRP]

Images

 
There are currently no images for Caldesmon/CALD1 Antibody (NBP2-54311H).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, IHC
Clone
CALD1/1424R
Clonality
Monoclonal
Host
Rabbit
Conjugate
HRP

Order Details

Novus Biologicals is part of Bio-Techne

Shop this product on bio-techne.com

Caldesmon/CALD1 Antibody (CALD1/1424R) [HRP] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Additional Information
Recombinant Monoclonal Antibody.
Immunogen
Recombinant human full-length Caldesmon/CALD1 protein (Uniprot: Q05682 )
Localization
Cytoplasmic
Marker
Smooth Muscle Marker
Specificity
Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120 150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70 80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This monoclonal antibody recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
CALD1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human and Rat. Others not known.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Alternate Names for Caldesmon/CALD1 Antibody (CALD1/1424R) [HRP]

  • CAD
  • CALD1
  • caldesmon 1
  • Caldesmon
  • CDM
  • CDMH-CAD
  • HCAD
  • LCAD
  • L-CAD
  • MGC21352
  • NAG22

Background

Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin (1,2). Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and actin-binding region at the C-terminus and a myosin-binding domain at the N-terminus (3). Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-actin. This inhibition is reduced by calcium-calmodulin and is promoted by tropomyosin (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-14871
Species: Mu, Rt
Applications: ICC/IF, WB
NB120-2860
Species: Ba, Bv, Ch, Hu, Mu, Rt
Applications: ELISA, Flow, ICC/IF, IHC, IHC-P, WB
NBP2-15669
Species: Hu, Mu, Rt
Applications: IHC-WhMt, IHC, WB
MAB4470
Species: All-Multi
Applications: ICC, IHC, WB
AF3844
Species: Hu, Mu
Applications: IHC
MAB1230
Species: Hu, Mu, Rt
Applications: ICC, IHC, KO, Simple Western, WB
NBP2-22203
Species: Hu, Pm, Mu, Rt
Applications: ELISA, Flow, ICC/IF, IHC, IHC-P, WB
NBP1-87744
Species: Hu
Applications: IHC, IHC-P, WB
NB300-223
Species: Bv, Ca, Ch, Eq, Hu, Mu, Po, Rt
Applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB
AF467
Species: Hu, Mu
Applications: CyTOF-ready, Flow, ICC, IHC, Simple Western, WB
NB600-1071
Species: Hu(-), Mu
Applications: ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
NBP2-62682
Species: Hu
Applications: IHC, IHC-P
AF7947
Species: Hu, Mu, Rt
Applications: ELISA, IHC, Simple Western, WB
MAB6896
Species: Hu, Mu, Rt
Applications: IHC, Simple Western, WB
NBP2-82026
Species: Hu, Mu, Rt
Applications: ELISA, ICC/IF, IHC, IHC-P, WB
NBP2-38323
Species: Hu
Applications: ICC/IF, IHC, IHC-P, WB
H00085366-M01
Species: Hu, Mu
Applications: ELISA, KD, WB
NBP2-54311H
Species: Hu, Rt
Applications: WB, IHC

Publications for Caldesmon/CALD1 Antibody (NBP2-54311H) (0)

There are no publications for Caldesmon/CALD1 Antibody (NBP2-54311H).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Caldesmon/CALD1 Antibody (NBP2-54311H) (0)

There are no reviews for Caldesmon/CALD1 Antibody (NBP2-54311H). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Caldesmon/CALD1 Antibody (NBP2-54311H) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Caldesmon/CALD1 Products

Diseases for Caldesmon/CALD1 Antibody (NBP2-54311H)

Discover more about diseases related to Caldesmon/CALD1 Antibody (NBP2-54311H).
 

Pathways for Caldesmon/CALD1 Antibody (NBP2-54311H)

View related products by pathway.

PTMs for Caldesmon/CALD1 Antibody (NBP2-54311H)

Learn more about PTMs related to Caldesmon/CALD1 Antibody (NBP2-54311H).
 

Research Areas for Caldesmon/CALD1 Antibody (NBP2-54311H)

Find related products by research area.

Blogs on Caldesmon/CALD1

There are no specific blogs for Caldesmon/CALD1, but you can read our latest blog posts.
mFluor Violet Conjugated Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Caldesmon/CALD1 Antibody (CALD1/1424R) [HRP] and receive a gift card or discount.

Bioinformatics

Gene Symbol CALD1