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beta-Catenin Antibody (OTI12H7) [Janelia Fluor® 669]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Pm, PmSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, CyTOF-ready
Clone
OTI12H7
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 669

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-70509AF350
Alexa Fluor 405
NBP2-70509AF405
Alexa Fluor 488
NBP2-70509AF488
Alexa Fluor 532
NBP2-70509AF532
Alexa Fluor 594
NBP2-70509AF594
Alexa Fluor 647
NBP2-70509AF647
Alexa Fluor 700
NBP2-70509AF700
Alexa Fluor 750
NBP2-70509AF750
Allophycocyanin
NBP2-70509APC
Biotin
NBP2-70509B
CoraFluor 1
NBP2-70509CL1
DyLight 350
NBP2-70509UV
DyLight 405
NBP2-70509V
DyLight 488
NBP2-70509G
DyLight 550
NBP2-70509R
DyLight 594
NBP2-70509DL594
DyLight 650
NBP2-70509C
DyLight 680
NBP2-70509FR
DyLight 755
NBP2-70509IR
FITC
NBP2-70509F
HRP
NBP2-70509H
Janelia Fluor 525
NBP2-70509JF525
Janelia Fluor 549
NBP2-70509JF549
Janelia Fluor 585
NBP2-70509JF585
Janelia Fluor 635
NBP2-70509JF635
Janelia Fluor 646
NBP2-70509JF646
PE
NBP2-70509PE
PerCP
NBP2-70509PCP
Unconjugated
NBP2-03615
mFluor Violet 450 SE
NBP2-70509MFV450
mFluor Violet 500 SE
NBP2-70509MFV500
mFluor Violet 610 SE
NBP2-70509MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-03615
Azide and BSA Free
NBP2-70509
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beta-Catenin Antibody (OTI12H7) [Janelia Fluor® 669] Summary

Immunogen
Full length human recombinant protein of human CTNNB1 (NP_001895) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CTNNB1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for beta-Catenin Antibody (OTI12H7) [Janelia Fluor® 669]

  • bCatenin
  • beta 1 (88kD)
  • beta-Catenin
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin beta-1
  • CTNNB
  • CTNNB1
  • DKFZp686D02253
  • FLJ25606
  • FLJ37923

Background

The protein encoded by the beta Catenin gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs arenecessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion betweencells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contactinhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this proteinbinds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this geneare a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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beta-Catenin Antibody (OTI12H7) [Janelia Fluor® 669]
Species: Hu, Mu, Rt, Pm, Pm
Applications: WB, Flow, ICC/IF, IHC, CyTOF-ready

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ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CTNNB1