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BDNF Antibody (35909) [HRP]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications CyTOF-ready, Flow
Clone
35909
Clonality
Monoclonal
Host
Mouse
Conjugate
HRP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC2481U-100UG
Alexa Fluor 405
IC2481V-100UG
Alexa Fluor 488
IC2481G-100UG
Alexa Fluor 532
FAB2481X
Alexa Fluor 594
IC2481T-100UG
Alexa Fluor 647
IC2481R-100UG
Alexa Fluor 700
IC2481N-100UG
Alexa Fluor 750
IC2481S-100UG
Allophycocyanin
IC2481A
Biotin
FAB2481B
DyLight 350
FAB2481D
DyLight 405
FAB2481E
DyLight 488
FAB2481K
DyLight 550
FAB2481L
DyLight 594
FAB2481M
DyLight 650
FAB2481W
DyLight 680
FAB2481Y
DyLight 755
FAB2481Z
FITC
FAB2481F
Janelia Fluor 525
FAB2481JF525
Janelia Fluor 549
FAB2481I
Janelia Fluor 646
FAB2481J
Janelia Fluor 669
FAB2481JF669
Phycoerythrin
IC2481P
Unconjugated
MAB2481
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB2481
Carrier Free
IC2481P
Carrier Free
IC2481A
Carrier Free
MAB2481
Carrier Free
MAB2481-SP
Carrier Free
IC2481V-100UG
Carrier Free
IC2481U-100UG
Carrier Free
IC2481T-100UG
Carrier Free
IC2481S-100UG
Carrier Free
IC2481R-100UG
Carrier Free
IC2481N-100UG
Carrier Free
IC2481G-100UG
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BDNF Antibody (35909) [HRP] Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human BDNF
His129-Arg247
Accession # P23560
Specificity
Detects human BDNF in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) NT-3, rhNT-4, or rh beta -NGF is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BDNF
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified from hybridoma culture supernatant

Alternate Names for BDNF Antibody (35909) [HRP]

  • Abrineurin
  • ANON2
  • BDNF
  • brain-derived neurotrophic factor
  • BULN2
  • MGC34632
  • Neurotrophin

Background

FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family. BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Research Areas for BDNF Antibody (FAB2481H)

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GFP, or green fluorescent protein, is a chemiluminescent protein derived from Aequorea jellyfish that was first discovered by Osamu Shimomura.  It was soon after established that the emission spectra of GFP was right around 509nm, or the ultraviol...  Read full blog post.
The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.
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TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...  Read full blog post.
TrkB and Nervous System Function
Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...  Read full blog post.
TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.
BDNF Antibodies Aid Research on Alzheimer's Therapies
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BDNF Antibodies and Synaptic Research
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophins. During development it regulates the survival and differentiation of neuronal cell populations in the central and peripheral nervous system, while in adult synapse...  Read full blog post.
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Bioinformatics

Gene Symbol BDNF