AMPK alpha 1 [p Ser496] Antibody

AMP-activated protein kinase (AMPK) is a metabolic and stress-sensing kinase that regulates homeostatis, and a key target for treating Type 2 diabetes and obesity. AMPK exists as a heterotrimeric complex comprised of catalytic alpha subunits (62 kDa) and non-catalytic beta and gamma subunits. Alpha subunit has at least two isoforms (alpha 1 and alpha 2) which differ in their subcellular localization and AMP-dependence. AMPK is phosphorylated by upstream kinases, AMPK Kinase (AMPKK) and LKB1 which results in its activation. Active AMPK regulates metabolism by phosphorylating rate-limiting enzymes in metabolic pathways and controlling gene expression. Phosphorylation of threonine 172 in the activation loop of the alpha subunit is a key determinant of AMPK activity.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Kohsuke Kataoka	WB	Mouse	02/07/2018	View Summary Application Western Blot Sample Tested Min6 mouse insulinoma whole cell lysate Species Mouse Lot 5616

Array NB100-81784

• AMPK alpha 1 Antibodies
• AMPK alpha 1 ELISA Kits
• AMPK alpha 1 Lysate
• AMPK alpha 1 Proteins
• AMPK alpha 1 ELISAs