ZBP1/DLM-1/DAI Antibody - BSA Free

Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: KD, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-76854	Applications	Species
Mutoh T, Kikuchi H, Jitsuishi T et al. Spatiotemporal expression patterns of ZBP1 in the brain of mouse experimental stroke model Journal of chemical neuroanatomy 2023-11-10 [PMID: 37952561]
Szczerba M, Johnson B, Acciai F et al. Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1 Science signaling 2023-03-14 [PMID: 36917643]
Nassour J, Aguiar LG, Correia A et al. Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis Nature 2023-02-01 [PMID: 36755096]
Shao R, Xie Q, Pan L et al. Necrostatin-1 attenuates Caspase-1-dependent pyroptosis induced by the RIPK1/ZBP1 pathway in ventilator-induced lung injury Cytokine 2022-09-01 [PMID: 35780712]
Du XK, Ge WY, Jing R, Pan LH Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1 Int. Immunopharmacol. 2019-10-23 [PMID: 31655343] (KD, WB, Mouse)	KD, WB	Mouse

Array NBP1-76854

• ZBP1/DLM-1/DAI Antibodies
• ZBP1/DLM-1/DAI Lysate
• ZBP1/DLM-1/DAI Proteins