WASP [p Ser483, p Ser484] Antibody

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using NB100-2307	Applications	Species
Stengel KR, Zheng Y. Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting. PLoS One 2012-01-01 [PMID: 22719838]
Sipes NS, Feng Y, Guo F et al. Cdc42 regulates extracellular matrix remodeling in three dimensions. J Biol Chem 2011-10-01 [PMID: 21880728]
Liu C, Miller H, Hui KL et al. A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. J Immunol 2011-07-01 [PMID: 21622861]
Nikolic DS, Lehmann M, Felts R et al. HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation. Blood. 2011-05-11 [PMID: 21562048]
Guo F, Hildeman D, Tripathi P et al. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proc Natl Acad Sci U S A 2010-10-01 [PMID: 20937872]
Guo F, Velu CS, Grimes HL et al. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood 2009-10-01 [PMID: 19671922]

Array NB100-2307

• WASP Antibodies
• WASP Lysate
• WASP Proteins