Rac1 Antibody

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. It is regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Rac 1: Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. The expression of isoform B is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues. Rac 2 is Hematopoietic specific. Defects in Rac 2 are the cause of neutrophil immunodeficiency syndrome.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Rabbit.

We have publications tested in 1 application: IF/IHC.

Showing Publications 1 - 5 of 5.

Publications using NB100-91266	Applications	Species
Manisaligil YA, Gumustekin M, Micili SC Et al. The role of small GTPase Rac1 in ionizing radiation-induced testicular damage International journal of radiation biology 2021-10-13 [PMID: 34597250] (IF/IHC, Rat)	IF/IHC	Rat
Yoon, Y M, Go, G Et al. Melatonin Suppresses Renal Cortical Fibrosis by Inhibiting Cytoskeleton Reorganization and Mitochondrial Dysfunction through Regulation of miR-4516. Int J Mol Sci 2020-07-27 [PMID: 32727098] (IF/IHC, Rabbit)	IF/IHC	Rabbit
Sylow L, Kleinert M, Pehmoller C et al. Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance. Cell Signal. 2013-11-09 [PMID: 24216610] (IF/IHC, Mouse)	IF/IHC	Mouse
Sylow L, Jensen TE, Kleinert M et al. Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin resistant murine and human skeletal muscle. Diabetes 2013-02-19 [PMID: 23423567]
Sylow L, Jensen TE, Kleinert M et al. Rac1 Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle. Diabetes 2012-12-28 [PMID: 23274900]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Chansol Hurr	IHC	Mouse	05/11/2017	View Summary Application Immunohistochemistry Sample Tested Brain (cerebral cortex),Mouse brain Species Mouse

Array NB100-91266

• Rac1 Antibodies
• Rac1 ELISA Kits
• Rac1 Lysate
• Rac1 Proteins