N-WASP Antibody

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-82512	Applications	Species
Frugtniet BA, Ruge F, Sanders AJ et al. nWASP Inhibition Increases Wound Healing via TrKb/PLC? Signalling Biomolecules 2023-02-17 [PMID: 36830748] (ICC/IF, Human)	ICC/IF	Human
Wang D, Ye Z, Wei W et al. Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors eLife 2021-11-19 [PMID: 34796874]
Faris R, McCullough A, Andersen SE et al. The Chlamydia trachomatis secreted effector TmeA hijacks the N-WASP-ARP2/3 actin remodeling axis to facilitate cellular invasion PLoS pathogens 2020-09-01 [PMID: 32946535] (ICC/IF, Human)	ICC/IF	Human
Bravo-Santano N, Stolting H, Cooper F et al. Host-directed kinase inhibitors act as novel therapies against intracellular Staphylococcus aureus Sci Rep 2019-03-19 [PMID: 30890742] (WB, Human)	WB	Human
Frugtniet BA, Martin TA, Zhang L, Jiang WG. Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion. BMC Cancer. 2017-03-28 [PMID: 28351346] (WB, Human)	WB	Human
Schell C, Baumhakl L, Salou S et al. N-WASP Is Required for Stabilization of Podocyte Foot Processes. J Am Soc Nephrol 2013-04-01 [PMID: 23471198] (ICC/IF, Mouse)	ICC/IF	Mouse
Yu X, Zech T, McDonald L et al. N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. J Cell Biol 2012-10-29 [PMID: 23091069]

Array NBP1-82512

• N-WASP Antibodies
• N-WASP Lysate
• N-WASP Proteins