A 17 residue synthetic peptide derived from C-terminal domain of rat VGLUT1.
Localization
Cell Membrane
Specificity
Reacts with rat 55-60 kDa VGLUT1 protein of BON cells stably expressing VGLUT1 and of total rat brain extracts. No cross reactivity was detected with VGLUT2 and VGLUT3
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC17A7
Purity
Immunogen affinity purified
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solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)
Solute carrier family 17 member 7
VGLUT1
VGLUT1vesicular glutamate transporter 1
Background
VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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