VEGFR2/KDR/Flk-1 Antibody

VEGFs such as VEGFA, VEGFC, VEGFD etc. activate RTKs namely VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt-4), that regulates angiogenic as well as lymphangiogenic transduction signals. VEGF Receptor 2 (VEGFR2) is the most prominent cell-surface receptor for VEGF ligands and binding of VEGFs to isoform 1 leads to multiple signaling cascades activation. PLCG1 activation results in production of signaling molecules (diacylglycerol, inositol 1,4,5-trisphosphate etc) and PKC activation. VEGFR2 is involved in the activation of MAPK1/ERK2, MAPK3/ERK1, and MAPK as well as AKT signaling pathways. It facilitates phosphorylation of PIK3R1 (regulatory subunit of PI3K), cytoskeletal actin reorganization and PTK2/FAK1 activation. VEGFR2 is essential for VEGFA-mediated induction of NOS2/NOS3, leading to the production of NO by endothelial cells and is involved in phosphorylation of FYN, NCK1, NOS3, PIK3R1 and SRC. Isoforms -2 and -3 function as decoy receptors for VEGFs, and isoform -2 plays as negative regulator of VEGFA/VEGFC-mediated lymphangiogenesis by limiting free VEGFA and/or VEGFC levels alongwith preventing their binding to VEGFR3. Versatile signaling effects by VEGFR2 leads to its regulatory role in processes such as angiogenesis, vascular development, vascular permeability, embryonic hematopoiesis, and promotes proliferation, survival, migration and differentiation of endothelial cells alongwith facilitating reorganization of the actin cytoskeleton.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 4 applications: FLOW, ICC/IF, IF/IHC, WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-530	Applications	Species
Liu X, Yu Z, Daitoku K et al. Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification Journal of Pharmacological Sciences 2021-02-01 [PMID: 33451756] (ICC/IF, Human)	ICC/IF	Human
Pianta, S;Lee, JY;Tuazon, JP;Castelli, V;Mantohac, LM;Tajiri, N;Borlongan, CV; A Short Bout of Exercise Prior to Stroke Improves Functional Outcomes by Enhancing Angiogenesis Neuromolecular Med. 2019-04-02 [PMID: 30941660] (IF/IHC, Rat)	IF/IHC	Rat
Qureshi R, Kindo M, Boulberdaa M et al. A prokineticin-driven epigenetic switch regulates human epicardial cell stemness and fate Stem Cells 2018-06-06 [PMID: 29873146] (FLOW, Human)	FLOW	Human
Motiani KK, Savolainen AM, Eskelinen JJ et al. Two weeks of moderate intensity continuous training, but not high intensity interval training increases insulin-stimulated intestinal glucose uptake. J. Appl. Physiol. 2017-02-09 [PMID: 28183816] (WB, Rat)	WB	Rat

Array NB100-530

• VEGFR2/KDR/Flk-1 Antibodies
• VEGFR2/KDR/Flk-1 Antibody Pair
• VEGFR2/KDR/Flk-1 ELISA Kits
• VEGFR2/KDR/Flk-1 Proteins
• VEGFR2/KDR/Flk-1 ELISAs
• VEGFR2/KDR/Flk-1 Proteins and Enzymes