Orthogonal Strategies: Immunohistochemistry-Paraffin: Tafazzin/TAZ Antibody [NBP1-88511] - Staining in human spleen and liver tissues.. Corresponding TAZ RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Tafazzin/TAZ Antibody [NBP1-88511] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: Tafazzin/TAZ Antibody [NBP1-88511] - Staining of human liver shows very weak membranous positivity in hepatocytes.
Immunohistochemistry-Paraffin: Tafazzin/TAZ Antibody [NBP1-88511] - Staining of human heart muscle shows moderate cytoplasmic positivity in cardiomyocytes.
Immunohistochemistry-Paraffin: Tafazzin/TAZ Antibody [NBP1-88511] - Staining of human spleen shows moderate membranous positivity in cells in red pulp.
This antibody was developed against Recombinant Protein corresponding to amino acids: WHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSALPVLERLRAENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNHLQP
Predicted Species
Mouse (95%), Rat (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TAFAZZIN
Purity
Immunogen affinity purified
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Human reactivity reported in scientific literature (PMID: 24858921).
Packaging, Storage & Formulations
Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for Tafazzin/TAZ Antibody
BTHSEFE
cardiomyopathy, dilated 3A (X-linked)
CMD3A
EFE2FLJ27390
G4.5endocardial fibroelastosis 2
LVNCX
Protein G4.5
tafazzin
Taz1
XAP-2
Background
Tafazzin / TAZ encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternative transcripts encoding additional isoforms have been described but the full-length nature of these transcripts is not known.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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