LDB3 Antibody (3C8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1 and 2) have C-terminal LIM domains. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ICC/IF.

Showing Publications 1 - 5 of 5.

Publications using H00011155-M06	Applications	Species
Pankaj P, Yotam B, Kalpana S et al. Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKC? and TSC2-mTOR downregulation. Commun Biol. 2021-03-19 [PMID: 33742095]
Teresinha E, Xaviere L, Pierre C et al. A Heterozygous Mutation in the Filamin C Gene Causes an Unusual Nemaline Myopathy With Ring Fibers. J Neuropathol Exp Neurol. 2020-06-30 [PMID: 32607581]
Scheffer DI, Shen J, Corey DP, Chen ZY. Gene Expression by Mouse Inner Ear Hair Cells during Development. J Neurosci 2015-04-22 [PMID: 25904789] (ICC/IF, Mouse)	ICC/IF	Mouse
Lin Xiaoyan, Ruiz Janelle, Bajraktari Ilda et al. Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP) mutations in the actin-binding domain cause disruption of skeletal muscle actin filaments in myofibrillar myopathy. J Biol Chem. 2014-05-09 [PMID: 24668811]
Arimura T, Inagaki N, Hayashi T et al. Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res. 2009-05-13 [PMID: 19377068]

Array H00011155-M06

• LDB3 Antibodies
• LDB3 Proteins