AlphaB Crystallin/CRYAB Antibody (OTI6A9)

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development,these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates.Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: Immunocytochemistry/ Immunofluorescence.

Showing Publication 1 - 1 of 1.

Publication using NBP1-47708	Applications	Species
Ueda S, Nishihara M, Hioka Y et al. Polo-Like Kinase 2 Plays an Essential Role in Cytoprotection against MG132-Induced Proteasome Inhibition via Phosphorylation of Serine 19 in HSPB5 International Journal of Molecular Sciences 2022-09-24 [PMID: 36232565] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	Immunoflurescence	Mouse	08/17/2021	View Summary Application Other Sample Tested muscle tissue Species Mouse Lot OTI6A9

Array NBP1-47708

• AlphaB Crystallin/CRYAB Antibodies
• AlphaB Crystallin/CRYAB ELISA Kits
• AlphaB Crystallin/CRYAB Lysate
• AlphaB Crystallin/CRYAB Proteins