LDB3 Products

Description

LDB3 encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1 and 2) have C-terminal LIM domains. [provided by RefSeq]

Bioinformatics

Entrez	11155 Human
Uniprot	AAH10929 Human NP_001073585.1 Human NP_009009.1 Human O75112 Human O75112-5 Human
Product By Gene ID	11155
Alternate Names	CMD1C CYPHER KIAA01613 KIAA0613FLJ35865 LDB3Z1 LDB3Z4 LIM domain binding 3 LIM domain-binding protein 3 ORACLE PDLIM6 PDZ and LIM domain 6 Protein cypher ZASPLVNC3 Z-band alternatively spliced PDZ-motif protein