Slit2 Antibody (984724) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Slit Homolog 2 (Slit2) is a member of the Slit family of secreted extracellular matrix glycoproteins that are best known for their role in axon guidance (1). It is widely expressed in the developing and adult brain and spinal cord, as well as in fetal lung and kidney, and the adult adrenal gland, thyroid gland, and trachea (1-3). Slit2 is composed of multiple domains including seven EGF-like domains, twenty Leucine-rich repeats (LRRs), one Laminin G-like domain, one C-terminal cysteine knot-like (CTCK) domain, and four N-terminal and four C-terminal LRR domains (1, 3). Slit2 has a molecular weight of approximately 200 kDa (4). However, proteolytic cleavage between the fifth and sixth EGF-like domains produces a membrane-bound 140 kDa N-terminal protein, termed Slit2-N, and a 55-60 kDa C-terminal fragment, termed Slit2-C (4, 5). Mature human Slit2 shares 96% amino acid sequence identity with the mouse and rat orthologs. Slit2 has been shown to have various important functions in the nervous system. Slit2 induces growth cone collapse, inhibits oligodendrocyte precursor cell migration, and promotes axon elongation, branch formation, and fasciculation (5-9). Slit2 C-terminal fragment can mediate axon guidance through binding to Plexin A1 receptor (10). Slit2-C has also been shown to bind to Glypican-1 and promote motor axon migration (5). Outside the nervous system, C-terminal fragment of Slit2 activates a thermogenic PKA pathway in adipocytes and improves glucose homeostasis (11).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB54443

• Slit2 Antibodies
• Slit2 ELISA Kits
• Slit2 Lysate
• Slit2 Proteins
• Slit2 Proteins and Enzymes