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SLC31A1/CTR1 Antibody [DyLight 650]

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SLC31A1/CRT1 was detected in immersion fixed NIH3T3 Mouse fibroblast cell line using Rabbit anti-SLC31A1/CRT1 Antigen Affinity-purified Polyclonal Antibody conjugated to DyLight 650 (Catalog # NB100-402C) (light blue) ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Ca, Xp, ZeSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 650

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SLC31A1/CTR1 Antibody [DyLight 650] Summary

Immunogen
A synthetic peptide derived from a C-terminal sequence of human SLC31A1/CTR1 [Uniprot: O15431]
Localization
Cell Membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC31A1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Canine reactivity reported in scientific literature (PMID: 29901089).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SLC31A1/CTR1 Antibody [DyLight 650]

  • Copper transporter 1
  • COPT1
  • COPT1high affinity copper uptake protein 1
  • CTR1
  • CTR1MGC75487
  • HCTR1
  • hCTR1copper transport 1 homolog
  • SLC31A1
  • solute carrier family 31 (copper transporters), member 1
  • Solute carrier family 31 member 1

Background

The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SLC31A1/CTR1 Antibody (NB100-402C) (0)

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Secondary Antibodies

 

Isotype Controls

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Research Areas for SLC31A1/CTR1 Antibody (NB100-402C)

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Blogs on SLC31A1/CTR1.

SLC31A1/CTR1 - a copper transporter with important implications for platinum-based chemotherapy
Copper is an essential micronutrient that serves as a cofactor in numerous biological processes, but can be toxic when present in excess. Because of this, cells must tightly maintain copper levels. This includes balance between import and export of...  Read full blog post.

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Bioinformatics

Gene Symbol SLC31A1