ATOX1 Antibody

ATOX1 (anti-oxidant 1 or HAH1) is an ATX1 family member and is a ubiquitously expressed metallochaperone which binds/deliver cytosolic copper to copper ATPase proteins. Copper is an essential trace element which at high concentration is extremely toxic and a balance between copper import/export is highly critical for survival. To ensure that the total pool of free copper is less than 1 ion per cell, ATOX1 specifically deliver copper to cellular compartments and copper-dependent enzymes. ATOX1 interacts with ATP7A (Menkes protein) and ATP7B (Wilson protein) in a copper-dependent manner leading to facilitation of copper transfer from ATOX1 to ATP7A or ATP7B, thus permitting copper transport into the secretory pathway and copper export from the cell. The conserved metal binding site of ATOX1, CxGC, differs from the metal-binding sites of Cu-transporting ATPases and has a physiologically relevant redox potential that equilibrates with the GSH: GSSH pair. Cellular functions of ATOX1 are not limited to its copper-trafficking role and may include storage of labile copper, modulation of transcription, and antioxidant defense.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-06611	Applications	Species
Flores AG, Unger VM. Atox1 Contains Positive Residues that Mediate Membrane Association and Aid Subsequent Copper Loading. J Membr Biol. 2013-09-15 [PMID: 24036897] (WB, Human)	WB	Human
Cai H, Peng F. Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells. Oncol Rep 2013-07-01 [PMID: 23624903]
Palm ME, Weise CF, Lundin C et al. Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro. Proc Natl Acad Sci U S A;108(17):6951-6. 2011-04-26 [PMID: 21482801]

Array NBP1-06611

• ATOX1 Antibodies
• ATOX1 Lysate
• ATOX1 Protein