SLC22A12 Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: SLC22A12 Antibody [NBP1-82500] - Analysis in human kidney and testis tissues using NBP1-82500 antibody. Corresponding SLC22A12 RNA-seq data are presented for ...read more
Immunohistochemistry-Paraffin: SLC22A12 Antibody [NBP1-82500] - Staining of human testis shows no positivity in cells in seminiferous ducts as expected.
Immunohistochemistry-Paraffin: SLC22A12 Antibody [NBP1-82500] - Staining of human kidney shows high expression.
Immunohistochemistry-Paraffin: SLC22A12 Antibody [NBP1-82500] - Staining of human lymph node shows no positivity in lymphoid cells as expected.
Immunohistochemistry-Paraffin: SLC22A12 Antibody [NBP1-82500] - Staining of human liver shows no positivity in hepatocytes as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

Order Details

SLC22A12 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: ESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCI
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SLC22A12
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
SLC22A12 Recombinant Protein Antigen (NBP1-82500PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for SLC22A12 Antibody

  • OATL4
  • Organic anion transporter 4-like protein
  • Renal-specific transporter
  • RST
  • RSTmember 12
  • SLC22A12
  • solute carrier family 22 (organic anion/urate transporter), member 12
  • UNQ6453/PRO34004
  • URAT1
  • URAT1Urate anion exchanger 1
  • urate transporter 1

Background

SLC22A12, also known as urate transporter 1 (URAT1), is a member of the organic cation/anion/zwitterion transporter family. This transporter is present on the epithelial cells of proximal tubules in the renal cortex and mediates urate uptake. Gene mutations or functional defects of URAT1 have been identified in patients with renal hypouricemia, which is characterized by low serum urate levels. Disorders associated with this condition include uric acid urolithiasis; hematuria; hypercalcemia; or occasionally, exercise-induced acute renal failure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SLC22A12