Sin1/MAPKAP1 Antibody

Sin1 is a novel component of the eukaryotic SAPK pathway. Sin1 and the H3 and H4 histones interact genetically, with the C terminus of Sin1 physically associating with components of the SWI-SNF complex. This interaction is blocked by the N-terminal half of the protein in full length Sin1. It has been proposed that Sin1 acts as a regulatable bridge between the SWI-SNF complex and the nucleosome Sin1 is also required for effective transcription via the AP-1 factor Pap1, but does not prevent its nuclear translocation. Sin1 is a novel component of the eukaryotic SAPK pathway.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, WB.

Showing Publications 1 - 7 of 7.

Publications using NB110-40424	Applications	Species
Huang Y, Feng G, Cai J et al. Sin1 promotes proliferation and invasion of prostate Cancer cells by modulating mTORC2-AKT and AR signaling cascades Life Sci. 2020-02-20 [PMID: 32088212] (IF/IHC)	IF/IHC
Cameron AJM, Veeriah S, Marshall JJT et al. Uncoupling TORC2 from AGC kinases inhibits tumour growth Oncotarget. 2017-10-17 [PMID: 29156676] (WB, Human)	WB	Human
Wang Q, Zhu J et al. Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma. Oncogene 2017-09-11 [PMID: 28692058] (WB, Human)	WB	Human
Das F, Ghosh-Choudhury N, Dey N et al. Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. J Biol Chem 2012-02-01 [PMID: 22184110]
Misra UK, Pizzo SV. Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex. J Cell Biochem 2012-05-01 [PMID: 22173835]
Lu M, Wang J, Ives HE et al. mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem 2011-09-01 [PMID: 21757730]
Huang J, Wu S, Wu CL et al. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res 2009-08-01 [PMID: 19602587]

Array NB110-40424

• Sin1/MAPKAP1 Antibodies
• Sin1/MAPKAP1 Lysates
• Sin1/MAPKAP1 Proteins