Serpin C1/Antithrombin-III Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: Serpin C1/Antithrombin-III Antibody [NBP2-15414] - Analysis of methanol-fixed HeLa, using antibody at 1:500 dilution.
Immunohistochemistry-Paraffin: Serpin C1/Antithrombin-III Antibody [NBP2-15414] - Paraffin-embedded human lung adenocarcinoma. Antithrombin III antibody diluted at 1:250.
Western Blot: Serpin C1/Antithrombin-III Antibody [NBP2-15414] -Human plasma (30 ug) was separated by 12% SDS-PAGE, and the membrane was blotted with Antithrombin III antibody diluted at 1:1000. The HRP-conjugated ...read more

Product Details

Summary
Reactivity Hu, RMSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Serpin C1/Antithrombin-III Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Serpin C1/Antithrombin-III. The exact sequence is proprietary.
Localization
Secreted; extracellular space
Predicted Species
Rhesus Macaque (91%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SERPINC1
Purity
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
Theoretical MW
53 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Mouse (88%), Rat (86%), Pig (87%), Sheep (86%), Bovine (84%), Guinea pig (85%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7), 20% Glycerol, 1% BSA
Preservative
0.01% Thimerosal
Purity
Antigen Affinity-purified

Alternate Names for Serpin C1/Antithrombin-III Antibody

  • Antithrombin-III
  • AT3antithrombin-III
  • ATIII
  • ATIIIantithrombin III
  • MGC22579
  • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
  • serine-cysteine proteinase inhibitor clade C member 1
  • Serpin C1
  • serpin peptidase inhibitor, clade C (antithrombin), member 1

Background

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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ICC/IF Video Protocol

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Bioinformatics

Gene Symbol SERPINC1
Uniprot