Human CXCL4/PF4 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCL4/PF4 is a secreted chemokine that is expressed by megakaryocytes and restrains the coagulation cascade. It is released by activated platelets and regulates Thrombin/Thrombomodulin complexes, activated Protein C (APC), Coagulation Factor Xa, and Fibrin. The anticoagulant heparin neutralizes CXCL4 procoagulant effects. Complexes of heparin and CXCL4 trigger antibody formation that causes the pathological syndrome HITT. Immunogenic complexes of CXCL4 with Apolipoprotein H contribute to antiphospholipid syndrome (APS). CXCL4 interferes with the proliferative and angiogenic functions of FGF-2 and VEGF. However, it can also exert proinflammatory and pro-atherogenic effects on monocytes, macrophages, and endothelial cells. CXCL4 may signal through CXCR3B in humans.

We have publications tested in 2 confirmed species: Human, Bovine.

Showing Publications 1 - 10 of 26. Show All 26 Publications. Collapse Publications.

Publications using DY795	Applications	Species
Delila, L;Nebie, O;Le, NTN;Timmerman, K;Lee, DY;Wu, YW;Chou, ML;Buée, L;Chou, SY;Blum, D;Devos, D;Burnouf, T; Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models Journal of biomedical science 2024-09-05 [PMID: 39237980] (Human)		Human
Lengvenyte, A;Cognasse, F;Hamzeh-Cognasse, H;Sénèque, M;Strumila, R;Olié, E;Courtet, P; Baseline circulating biomarkers, their changes, and subsequent suicidal ideation and depression severity at 6 months: A prospective analysis in patients with mood disorders Psychoneuroendocrinology 2024-07-06 [PMID: 39003840] (Human)		Human
Lekva, T;Sundaram, AYF;Roland, MCP;Åsheim, J;Michelsen, AE;Norwitz, ER;Aukrust, P;Gilfillan, GD;Ueland, T; Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study BMC medicine 2023-11-23 [PMID: 37996819] (Human)		Human
J Jiang, X Cong, S Alageel, U Dornseifer, AF Schilling, E Hadjipanay, HG Machens, P Moog In Vitro Comparison of Lymphangiogenic Potential of Hypoxia Preconditioned Serum (HPS) and Platelet-Rich Plasma (PRP) International Journal of Molecular Sciences, 2023-01-19;24(3):. 2023-01-19 [PMID: 36768283] (Human)		Human
I Pietrafort, A Butera, L Gaddini, A Mennella, R Palazzo, D Campanile, K Stefananto, V Riccieri, R Lande, L Frasca CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614095] (Human)		Human
MH Schutte, R Kleemann, NM Nota, CM Wiepjes, JM Snabel, G T'Sjoen, A Thijs, M den Heijer The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasis PLoS ONE, 2022-03-15;17(3):e0261312. 2022-03-15 [PMID: 35290388] (Human)		Human
PC Duque-Madr, J Velasco-Bo, A Ceballos-M, C López, JU Carmona Intramammary treatment using allogeneic pure platelet-rich plasma in cows with subclinical mastitis caused by Gram-positive bacteria Scientific Reports, 2021-12-09;11(1):23737. 2021-12-09 [PMID: 34887474] (Bovine)		Bovine
A Dickhout, DM Kaczor, ACA Heinzmann, SLN Brouns, JWM Heemskerk, MAMJ van Zandvo, RR Koenen Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells International Journal of Molecular Sciences, 2021-07-08;22(14):. 2021-07-08 [PMID: 34298951] (Human)		Human
A Dickhout, BME Tullemans, JWM Heemskerk, VLJL Thijssen, MJE Kuijpers, RR Koenen Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro PLoS ONE, 2021-01-07;16(1):e0244736. 2021-01-07 [PMID: 33411760] (Human)		Human
MR Cooperberg, JE Cowan, KJ Lindquist, Y Kobayashi, JP Simko, H Bengtsson, K Singh, V Ngo, A Avila, LF Newcomb, M Tretriakov, DW Lin, S Stone, PR Carroll, PL Paris Multiple Tissue Biomarkers Independently and Additively Predict Prostate Cancer Pathology Outcomes Eur Urol, 2020-11-02;0(0):. 2020-11-02 [PMID: 33148472] (Human)		Human
CC Lopez Yoma, KT Preissner, B Lorenz, K Stieger Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants Sci Rep, 2019-05-01;9(1):6744. 2019-05-01 [PMID: 31043645] (Human)		Human
R Lande, EY Lee, R Palazzo, B Marinari, I Pietrafort, GS Santos, Y Mattenberg, F Spadaro, K Stefananto, N Iannace, AM Dufour, M Falchi, M Bianco, E Botti, L Bianchi, M Alvarez, V Riccieri, ME Truchetet, G C L Wong, C Chizzolini, L Frasca CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-? production in systemic sclerosis Nat Commun, 2019-05-01;10(1):1731. 2019-05-01 [PMID: 31043596] (Human)		Human
TG Walsh, A Wersäll, AW Poole Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets Cell. Signal., 2019-03-14;0(0):. 2019-03-14 [PMID: 30880223] (Human)		Human
T Barwari, S Eminaga, U Mayr, R Lu, PC Armstrong, MV Chan, M Sahraei, M Fernández-, T Moreau, J Barallobre, M Lynch, X Yin, C Schulte, F Baig, R Pechlaner, SR Langley, A Zampetaki, P Santer, M Weger, R Plasenzott, M Schosserer, J Grillari, S Kiechl, J Willeit, AM Shah, C Ghevaert, TD Warner, C Fernández-, Y Suárez, M Mayr Inhibition of profibrotic microRNA-21 affects platelets and their releasate JCI Insight, 2018-11-02;3(21):. 2018-11-02 [PMID: 30385722] (Human)		Human
GJ Nieuwenhui, TAJ van den Be, SJL Bakker, MC van den He, MMRF Struys, T Lisman, RA Pol Preemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors PLoS ONE, 2018-07-16;13(7):e0200537. 2018-07-16 [PMID: 30011293] (Human)		Human
CC Mok, S Soliman, LY Ho, FA Mohamed, FI Mohamed, C Mohan Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis Arthritis Res. Ther., 2018-01-11;20(1):6. 2018-01-11 [PMID: 29325582] (Human)		Human
S Sabrkhany, MJE Kuijpers, SMJ van Kuijk, L Sanders, S Pineda, SWM Olde Damin, AC Dingemans, AW Griffioen, MGA Oude Egbri A combination of platelet features allows detection of early-stage cancer Eur. J. Cancer, 2017-05-17;80(0):5-13. 2017-05-17 [PMID: 28527393] (Human)		Human
David M Briscoe Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients J. Heart Lung Transplant., 2016-10-03;0(0):. 2016-10-03 [PMID: 27865734] (Human)		Human
Joseph W Jackson Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis PLoS ONE, 2016-06-06;11(6):e0157115. 2016-06-06 [PMID: 27270236] (Human)		Human
Conroy A, Gelvez M, Hawkes M, Rajwans N, Liles W, Villar-Centeno L, Kain K Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study. BMC Infect Dis, 2014-01-20;14(0):35. 2014-01-20 [PMID: 24444080] (Human)		Human
L van Bon, AJ Affandi, J Broen, RB Christmann, RJ Marijnisse, L Stawski, GA Farina, G Stifano, AL Mathes, M Cossu, M York, C Collins, M Wenink, R Huijbens, R Hesselstra, T Saxne, M DiMarzio, D Wuttge, SK Agarwal, JD Reveille, S Assassi, M Mayes, Y Deng, JP Drenth, J de Graaf, M den Heijer, CG Kallenberg, M Bijl, A Loof, WB van den Be, LA Joosten, V Smith, F de Keyser, R Scorza, C Lunardi, PL van Riel, M Vonk, W van Heerde, S Meller, B Homey, L Beretta, M Roest, M Trojanowsk, R Lafyatis, TR Radstake Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis N. Engl. J. Med, 2013-12-18;370(5):433-43. 2013-12-18 [PMID: 24350901] (Human)		Human
Chatterjee M, Huang Z, Zhang W, Jiang L, Hultenby K, Zhu L, Hu H, Nilsson GP, Li N Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli. Blood, 2011-02-17;117(14):3907-11. 2011-02-17 [PMID: 21330475] (Human)		Human
de Mast Q, de Groot PG, van Heerde WL, Roestenberg M, van Velzen JF, Verbruggen B, Roest M, McCall M, Nieman AE, Westendorp J, Syafruddin D, Fijnheer R, van Dongen-Lases EC, Sauerwein RW, van der Ven AJ Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br. J. Haematol., 2010-10-19;151(5):495-503. 2010-10-19 [PMID: 20955404] (Human)		Human
Dubrac A, Quemener C, Lacazette E, Lopez F, Zanibellato C, Wu WG, Bikfalvi A, Prats H Functional divergence between 2 chemokines is conferred by single amino acid change. Blood, 2010-08-05;116(22):4703-11. 2010-08-05 [PMID: 20688960] (Human)		Human
Peterson JE, Zurakowski D, Italiano JE Normal ranges of angiogenesis regulatory proteins in human platelets. Am. J. Hematol., 2010-07-01;85(7):487-93. 2010-07-01 [PMID: 20575035] (Human)		Human
Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood, 2008-07-29;112(8):3154-63. 2008-07-29 [PMID: 18664625] (Human)		Human
Show All 26 Publications. Collapse Publications.

Array DY795

• CXCL4/PF4 Antibodies
• CXCL4/PF4 ELISA Kits
• CXCL4/PF4 Lysate
• CXCL4/PF4 Proteins
• CXCL4/PF4 Proteins and Enzymes
• CXCL4/PF4 ELISAs