Senataxin Antibody [DyLight 488] Summary
Immunogen |
A partial recombinant protein made to an internal portion of the human Senataxin protein (between residues 600-750) [UniProt Q7Z333] |
Localization |
Nucleus, nucleoplasm, nucleolus. Cytoplasm. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
SETX |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry
- Immunocytochemistry/ Immunofluorescence
- Immunohistochemistry
- Immunohistochemistry-Paraffin
- Immunoprecipitation
- Western Blot
|
Application Notes |
Optimal dilution of this antibody should be experimentally determined. |
Reactivity Notes
Mouse reactivity reported in scientific literature (PMID: 28245518).
Packaging, Storage & Formulations
Storage |
Store at 4C in the dark. |
Buffer |
50mM Sodium Borate |
Preservative |
0.05% Sodium Azide |
Purity |
Immunogen affinity purified |
Notes
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Alternate Names for Senataxin Antibody [DyLight 488]
Background
Senataxin (SETX, ALS4, AOA2, SCAR1) belongs to the DNA/NAM7 helicase family. The protein encoded for by Senataxin has a DNA/RNA helicase domain at its C-terminal end. Senataxin may play a role in RNA maturation. It may also be involved in DNA double-strand breaks damage response caused by oxidative stress. Cellular localization of Senataxin is limited to the nucleus and cytoplasm. Senataxin is abundantly expressed in skeletal muscle. Expression of Senataxin is also seen in heart, fibroblast, placenta, liver, and weakly in brain and lung. Post translational modifications of Senataxin include acetylation and phosphorylation. There are 3 known isoforms (302.9, 299.4 and 306.3 kDa).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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