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SDHB Antibody (SDHB/2382) [Janelia Fluor® 585]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, MA
Clone
SDHB/2382
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 585

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-08537AF350
Alexa Fluor 405
NBP3-08537AF405
Alexa Fluor 488
NBP3-08537AF488
Alexa Fluor 532
NBP3-08537AF532
Alexa Fluor 594
NBP3-08537AF594
Alexa Fluor 647
NBP3-08537AF647
Alexa Fluor 700
NBP3-08537AF700
Alexa Fluor 750
NBP3-08537AF750
Allophycocyanin
NBP3-08537APC
Biotin
NBP3-08537B
CoraFluor 1
NBP3-08537CL1
DyLight 350
NBP3-08537UV
DyLight 405
NBP3-08537V
DyLight 488
NBP3-08537G
DyLight 550
NBP3-08537R
DyLight 594
NBP3-08537DL594
DyLight 650
NBP3-08537C
DyLight 680
NBP3-08537FR
DyLight 755
NBP3-08537IR
FITC
NBP3-08537F
HRP
NBP3-08537H
Janelia Fluor 525
NBP3-08537JF525
Janelia Fluor 549
NBP3-08537JF549
Janelia Fluor 635
NBP3-08537JF635
Janelia Fluor 646
NBP3-08537JF646
Janelia Fluor 669
NBP3-08537JF669
PE
NBP3-08537PE
PerCP
NBP3-08537PCP
Unconjugated
NBP3-08537
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-08537
Azide and BSA Free
NBP3-08537
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SDHB Antibody (SDHB/2382) [Janelia Fluor® 585] Summary

Immunogen
Recombinant fragment (around aa 165-273) of human SDHB protein (exact sequence is proprietary) (Uniprot: P21912)
Localization
Cytoplasmic (Mitochondria)
Marker
Pheochromocytoma Marker
Specificity
Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SDHB
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Protein Array
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for SDHB Antibody (SDHB/2382) [Janelia Fluor® 585]

  • EC 1.3.5.1
  • FLJ92337
  • IP
  • Iron-sulfur subunit of complex II
  • PGL4
  • SDH
  • SDH1
  • SDH2
  • SDHIP
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Background

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SDHB