RNF111 Antibody (1C4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using H00054778-M05	Applications	Species
Victor L, Florent D, Sadek A et al. Quantitative ubiquitylome analysis reveals specificity of RNF111/Arkadia E3 ubiquitin ligase for its degradative substrates SKI and SKIL/SnoN in TGF-? signaling pathway. Mol Cell Proteomics. 2021-11-03 [PMID: 34740826]
Y Sun, LM Miller Jen, YP Su, KC Nitiss, JL Nitiss, Y Pommier A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation Sci Adv, 2020-11-13;6(46):. 2020-11-13 [PMID: 33188014]
McIntosh DJ, Walters TS, Arinze IJ et al. Arkadia (RING Finger Protein 111) Mediates Sumoylation-Dependent Stabilization of Nrf2 Through K48-Linked Ubiquitination. Cell Physiol Biochem 2018-03-23 [PMID: 29597191]
van Cuijk L, van Belle GJ, Turkyilmaz Y et al. SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair. Nat Commun. 2015-07-07 [PMID: 26151477]
Gonzalez-Prieto R, Cuijpers SA, Kumar R et al. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. Cell Cycle 2015-01-01 [PMID: 25895136] (WB)	WB
Poulsen SL, Hansen RK, Wagner SA et al. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. J Cell Biol. 2013-06-10 [PMID: 23751493]
Erker Y, Neyret-Kahn H, Seeler JS et al. Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation. Mol Cell Biol. 2013-03-25 [PMID: 23530056]
Ma T, Chen Y, Zhang F et al. RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination. Mol Cell. 2013-02-07 [PMID: 23394999]
Koinuma D, Shinozaki M, Nagano Y et al. RB1CC1 positively regulates transforming growth factor-{beta} signaling through the modulation of Arkadia E3 ubiquitin ligase activity. J Biol Chem. 2011-07-27 [PMID: 21795712]
Javelaud D, van Kempen L, Alexaki VI et al. Efficient TGF-beta/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression. Mol Cancer. 2011-01-06 [PMID: 21211030]
Nagano Y, Koinuma D, Miyazawa K, Miyazono K. Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells. J Biochem. 2009-12-02 [PMID: 19959502]
Smith-McCune, Fishman D, Gray JW et al. Overexpression of snon/skil, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis. Molecular Oncology 10.1016/ j.molonc. 2008.05.001. 2008-01-01 [PMID: 19383336]
Levy L, Howell M, Das D et al. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol;27(17):6068-83. 2007-09-01 [PMID: 17591695]
Show All 13 Publications. Collapse Publications.

Array H00054778-M05

• RNF111 Antibodies
• RNF111 Protein