Recombinant Rat CXCL1/CINC-1 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCL1, also known as KC, GRO alpha , and CINC-1, is an approximately 8 kDa proinflammatory chemokine that plays a key role in neutrophil migration and activation (1). Mature rat CXCL1 shares 67% and 92% aa sequence identity with human and mouse CXCL1, respectively (2, 3). It is produced by many cell types in inflammatory sites and during chronic inflammatory diseases (1). CXCL1 can associate into bioactive dimers and primarily signals through CXCR2/IL-8 RB but can also bind with lower affinity to CXCR2/IL-8 RA (4-6). It induces neutrophil migration, extravasation, respiratory burst, and degranulation and also induces T cells to produce proinflammatory IL-17 (5, 7, 8). CXCL1 additionally binds to Syndecan-1 on epithelial cells which acts as a sink for CXCL1 activity until Syndecan-1 cleavage by MMP-7 (9). CXCL1 is up-regulated in spinal cord astrocytes by inflammatory stimuli or tumor cell injection, and it exacerbates pain sensation by potentiating excitatory NMDA neurotransmission (10, 11). In the circulatory system, CXCL1 interacts with CXCR2 on endothelial cells to promote lymphatic tube formation and angiogenesis (12, 13). It promotes the hypertrophic differentiation of chondrocytes resulting in cartilage matrix deposition, calcification, and remodeling (14). It interacts with both CXCR1 and CXCR2 on adipose stromal cells and promotes their recruitment to prostate tumors in obese patients (15). It also binds CXCR2 on ovarian cancer cells, leading to cleavage of cell surface HB-EGF, transactivation of EGF R, and cell proliferation (16).

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 4 applications: Binding Assay, Bioassay, ELISA (Standard), In Vivo.

Showing Publications 1 - 6 of 6.

Publications using 515-CN	Applications	Species
M Murata, K Noda, S Yoshida, M Saito, A Fujiya, A Kanda, S Ishida Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration Invest. Ophthalmol. Vis. Sci., 2019-10-01;60(13):4425-4435. 2019-10-01 [PMID: 31652327] (Bioassay, Rat)	Bioassay	Rat
H Ni, Y Wang, K An, Q Liu, L Xu, C Zhu, H Deng, Q He, T Wang, M Xu, Y Zheng, B Huang, J Fang, M Yao Crosstalk between NF?B-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation J Neuroinflammation, 2019-01-03;16(1):1. 2019-01-03 [PMID: 30606213] (In Vivo, Rat)	In Vivo	Rat
Suzukawa , Keigo, Tomlin , Julia, Pak , Kwang, Chavez , Eduardo, Kurabi , Arwa, Baird , Andrew, Wasserman , Stephen, Ryan , Allen F A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation. PLoS ONE, 2014-07-17;9(7):e102739. 2014-07-17 [PMID: 25033458] (Bioassay, Rat)	Bioassay	Rat
Russo TA, Beanan JM, Olson R, MacDonald U, Luke NR, Gill SR, Campagnari AA Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology. Infect. Immun., 2008-06-09;76(8):3577-86. 2008-06-09 [PMID: 18541654] (ELISA (Standard))	ELISA (Standard)
Fan X, Patera AC, Pong-Kennedy A, Deno G, Gonsiorek W, Manfra DJ, Vassileva G, Zeng M, Jackson C, Sullivan L, Sharif-Rodriguez W, Opdenakker G, Van Damme J, Hedrick JA, Lundell D, Lira SA, Hipkin RW Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J. Biol. Chem., 2006-12-29;282(16):11658-66. 2006-12-29 [PMID: 17197447] (Binding Assay, Mouse)	Binding Assay	Mouse
Rhodes KE, Raivich G, Fawcett JW The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience, 2006-04-21;140(1):87-100. 2006-04-21 [PMID: 16631314] (In Vivo, Rat)	In Vivo	Rat

Array 515-CN

• CXCL1/GRO alpha/KC/CINC-1 Antibodies
• CXCL1/GRO alpha/KC/CINC-1 ELISA Kit
• CXCL1/GRO alpha/KC/CINC-1 Proteins
• CXCL1/GRO alpha/KC/CINC-1 Proteins and Enzymes
• CXCL1/GRO alpha/KC/CINC-1 ELISAs