Recombinant Mouse CXCL12/SDF-1 alpha Protein

Name: Recombinant Mouse CXCL12/SDF-1 alpha Protein
Brand: Novus Biologicals
SKU: 460-SD
Price: 294 USD

(86 Publications)

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Recombinant Mouse CXCL12/SDF-1 alpha (Catalog # 460-SD) chemoattracts the BaF3 mouse pro-B cells transfected with human CXCR4. The ED50 for this effect is0.15-0.6 ng/mL.

1 μg/lane of Recombinant Mouse CXCL12/SDF-1 alpha was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	Bioactivity

Order Details

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Catalog# & Formulation	Size	Price
Carrier Free 460-SD-010/CF

Carrier Free 460-SD-050/CF

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Recombinant Mouse CXCL12/SDF-1 alpha Protein Summary

Details of Functionality	Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR4. The ED₅₀ for this effect is 0.15-0.6 ng/mL. Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL). The ED₅₀ for this effect is 3-9 ng/mL.
Source	E. coli-derived mouse CXCL12/SDF-1 alpha protein Lys22-Lys89
Accession #	P40224
N-terminal Sequence	Lys22
Protein/Peptide Type	Recombinant Proteins
Gene	Cxcl12
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note	<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity
Bioactivity2

Theoretical MW

8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Publications

Read Publications using
460-SD in the following applications:

Bioassay
76 publications
Cell Culture
3 publications
ELISA (Capture)
1 publication
In Vivo
3 publications
In vivo assay
1 publication
Multiplex Standard
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse CXCL12/SDF-1 alpha Protein

CXCL12 chemokine (C-X-C motif) ligand 12
CXCL12/SDF-1 alpha
IRH
PBSF
SCYB12
SDF1 alpha
SDF1
SDF1a
SDF1B
TLSF
TPAR1

Background

SDF-1 alpha and SDF-1 beta , members of the chemokine alpha subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line as cytokines that supported the proliferation of a stromal cell‑dependent pre-B-cell line, and were named Pre‑B‑Cell Growth Stimulating Factor (PBSF). SDF‑1 alpha and SDF‑1 beta cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1 alpha and SDF‑1 beta are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy‑terminus of SDF-1 beta and absent from SDF‑1 alpha . SDF‑1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF‑1/PBSF acts via the chemokine receptor CXCR4 and has been shown to be a chemoattractant for T‑lymphocytes, monocytes, pro- and pre- B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 have been found to have impaired B‑lymphopoiesis, myelopoiesis, vascular development, cardiogenesis and abnormal neuronal cell migration and patterning in the central nervous system.

Ma, Q. et al. (1998) Proc. Natl. Acad. Sci. USA 95:9448.
Zou, Y.R. et al. (1998) Nature 393:595.
Tachibana, K. et al. (1998) Nature 393:591.

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Publications for CXCL12/SDF-1 alpha (460-SD)(86)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Ovine, Transgenic Mouse.

We have publications tested in 6 applications: Bioassay, Cell Culture, ELISA (Capture), In Vivo, In vivo assay, Multiplex Standard.

Showing Publications 1 - 10 of 86. Show All 86 Publications.

Publications using 460-SD	Applications	Species
Anastasiadou, DP;Couturier, N;Goel, S;Argyris, DG;Vodopyanov, S;Rivera-Sanchez, L;Gonzalez, E;Kreger, J;Griffen, A;Kazakov, A;Burt, J;Recoder, N;Duran, CL;Harney, AS;Quesnel, A;Filippou, PS;Lenis, VP;Shukla, S;Entenberg, D;Zintiridou, A;Chen, X;Eddy, RJ;Oktay, MH;Condeelis, JS;Karagiannis, NS;Briceno, A;Guzik, H;Alon, R;DesMarais, V;Ioannou, G;Gnjatic, S;Raynolds, DM;Macedo, R;Reshef, R;Gil-Henn, H;MacLean, AL;Torres, ER;LaFave, LM;Lauvau, G;Karagiannis, GS; Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer bioRxiv : the preprint server for biology 2024-10-18 [PMID: 39464015] (In vivo assay, Transgenic Mouse)	In vivo assay	Transgenic Mouse
Kim, SK;Tran, LT;NamKoong, C;Choi, HJ;Chun, HJ;Lee, YH;Cheon, M;Chung, C;Hwang, J;Lim, HH;Shin, DM;Choi, YH;Kim, KW; Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons Nature communications 2023-07-19 [PMID: 37468558] (Bioassay, Human)	Bioassay	Human
YP Jiang, JJ Wen, XX Zhao, YC Gao, X Ma, SY Song, Y Jin, TJ Shao, J Yu, CP Wen The Flavonoid Naringenin Alleviates Collagen-Induced Arthritis through Curbing the Migration and Polarization of CD4+ T Lymphocyte Driven by Regulating Mitochondrial Fission International Journal of Molecular Sciences, 2022-12-23;24(1):. 2022-12-23 [PMID: 36613721] (Cell Culture, Mouse)	Cell Culture	Mouse
V Penna, N Moriarty, Y Wang, KCL Law, CW Gantner, RJ Williams, DR Nisbet, CL Parish Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson's Disease International Journal of Molecular Sciences, 2022-04-22;23(9):. 2022-04-22 [PMID: 35563037] (Bioassay, Mouse)	Bioassay	Mouse
S Sevilla-Mo, P Fuentes, Y Rodríguez-, N Arellano-S, PW Krenn, SI de Val, S Montero-He, J García-Cec, V Burdiel-He, SR Gardeta, N Aguilera-M, C Barrio-Alo, G Crainiciuc, D Bouvard, A García-Par, AG Zapata, A Hidalgo, R Fässler, YR Carrasco, ML Toribio, J Teixidó ICAP-1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice European Journal of Immunology, 2022-05-13;0(0):. 2022-05-13 [PMID: 35491946] (Bioassay, Mouse)	Bioassay	Mouse
W Piao, L Li, V Saxena, J Iyyathurai, R Lakhan, Y Zhang, IT Lape, C Paluskievi, KL Hippen, Y Lee, E Silverman, MW Shirkey, LV Riella, BR Blazar, JS Bromberg PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration Nature Communications, 2022-04-21;13(1):2176. 2022-04-21 [PMID: 35449134] (Bioassay, Mouse)	Bioassay	Mouse
AP Nugraha, H Kitaura, F Ohori, A Pramusita, S Ogawa, T Noguchi, A Marahleh, Y Nara, R Kinjo, I Mizoguchi C?X?C receptorï¿½7 agonist acts as a C?X?C motif chemokine ligandï¿½12 inhibitor to ameliorate osteoclastogenesis and bone resorption Molecular Medicine Reports, 2022-01-11;25(3):. 2022-01-11 [PMID: 35014674] (Bioassay, Mouse)	Bioassay	Mouse
C Liu, L Ma, Y Wang, J Zhao, P Chen, X Chen, Y Wang, Y Hu, Y Liu, X Jia, Z Yang, X Yin, J Wu, S Wu, H Zheng, X Ma, X Sun, Y He, L Lin, Y Fu, K Liao, X Zhou, S Jiang, G Fu, J Tang, W Han, XL Chen, W Fan, Y Hong, J Han, X Huang, BA Li, N Xiao, C Xiao, G Fu, WH Liu Glycogen synthase kinase 3 drives thymocyte egress by suppressing beta-catenin activation of Akt Science Advances, 2021-10-08;7(41):eabg6262. 2021-10-08 [PMID: 34623920] (Bioassay, Mouse)	Bioassay	Mouse
AT Ehrlich, M Semache, P Couvineau, S Wojcik, H Kobayashi, M Thelen, F Gross, M Hogue, C Le Gouill, E Darcq, M Bouvier, BL Kieffer Ackr3-Venus knock-in mouse lights up brain vasculature Molecular Brain, 2021-09-28;14(1):151. 2021-09-28 [PMID: 34583741] (Bioassay, Mouse)	Bioassay	Mouse
Z Benet, Z Jing, DR Fooksman Plasma cell dynamics in the bone marrow niche Cell Reports, 2021-02-09;34(6):108733. 2021-02-09 [PMID: 33567286] (Bioassay, Mouse)	Bioassay	Mouse
K Spinler, J Bajaj, T Ito, B Zimdahl, M Hamilton, A Ahmadi, CS Koechlein, N Lytle, HY Kwon, F Anower-E-K, H Sun, A Blevins, J Weeks, M Kritzik, J Karlseder, MH Ginsberg, PW Park, JD Esko, T Reya A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia Nat Commun, 2020-11-26;11(1):5998. 2020-11-26 [PMID: 33243988] (Bioassay, Mouse)	Bioassay	Mouse
C Peligero-C, T Givony, A Sebé-Pedró, J Dobeš, N Kadouri, S Nevo, F Roncato, R Alon, Y Goldfarb, J Abramson IL18 signaling promotes homing of mature Tregs into the thymus Elife, 2020-07-20;9(0):. 2020-07-20 [PMID: 32687059] (Bioassay, Mouse)	Bioassay	Mouse
E Haring, FM Uhl, G Andrieux, M Proietti, A Bulashevsk, B Sauer, LM Braun, E de Vega Go, PR Esser, SF Martin, D Pfeifer, M Follo, A Schmitt-Gr, J Buescher, J Duyster, B Grimbacher, M Boerries, EL Pearce, R Zeiser, P Apostolova Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect Haematologica, 2021-08-01;0(0):. 2021-08-01 [PMID: 32675222] (Cell Culture, Mouse)	Cell Culture	Mouse
W Su, J Yu, Q Liu, L Ma, Y Huang CXCL12/CXCR4 signaling induced itch and pain sensation in a murine model of allergic contact dermatitis Mol Pain, 2020-01-01;16(0):1744806920926. 2020-01-01 [PMID: 32418467] (In Vivo, Mouse)	In Vivo	Mouse
Y Hattori, Y Naito, Y Tsugawa, S Nonaka, H Wake, T Nagasawa, A Kawaguchi, T Miyata Transient microglial absence assists postmigratory cortical neurons in proper differentiation Nat Commun, 2020-04-02;11(1):1631. 2020-04-02 [PMID: 32242005] (Bioassay, Mouse)	Bioassay	Mouse
S Giannini, MM Lee-Sundlo, L Rivadeneyr, CA Di Buduo, R Burns, JT Lau, H Falet, A Balduini, KM Hoffmeiste beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis Nat Commun, 2020-01-17;11(1):356. 2020-01-17 [PMID: 31953383] (Bioassay, Mouse)	Bioassay	Mouse
S Giannini, MM Lee-Sundlo, L Rivadeneyr, CA Di Buduo, R Burns, JT Lau, H Falet, A Balduini, KM Hoffmeiste beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis Nat Commun, 2020;11(1):356. 2020 [PMID: 31953383] (Bioassay, Mouse)	Bioassay	Mouse
JM Bertho, D Kereselidz, L Manens, C Culeux, V Magneron, J Surette, M Blimkie, L Bertrand, H Wyatt, M Souidi, I Dublineau, N Priest, JR Jourdain Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism Sci Rep, 2019-12-27;9(1):19919. 2019-12-27 [PMID: 31882739] (Multiplex Standard, Mouse)	Multiplex Standard	Mouse
Y Cui, Y Yin, Z Xiao, Y Zhao, B Chen, B Yang, B Xu, H Song, Y Zou, X Ma, J Dai LncRNA Neat1 mediates miR-124-induced activation of Wnt/beta-catenin signaling in spinal cord neural progenitor cells Stem Cell Res Ther, 2019-12-18;10(1):400. 2019-12-18 [PMID: 31852544] (Bioassay, Mouse)	Bioassay	Mouse
M Mandal, MK Okoreeh, DE Kennedy, M Maienschei, J Ai, KC McLean, N Kaverina, M Veselits, I Aifantis, F Gounari, MR Clark CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis Nat. Immunol., 2019-09-02;0(0):. 2019-09-02 [PMID: 31477919] (Bioassay, Mouse)	Bioassay	Mouse
H Park, S Lad, K Boland, K Johnson, N Readio, G Jin, S Asfaha, KS Patterson, A Singh, X Yang, D Londono, A Singh, C Trempus, D Gordon, TC Wang, RJ Morris Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms Nat Commun, 2018-12-13;9(1):5293. 2018-12-13 [PMID: 30546048] (Bioassay, Mouse)	Bioassay	Mouse
L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming Cell Rep, 2018-12-11;25(11):3059-3073.e10. 2018-12-11 [PMID: 30540939] (Bioassay, Mouse)	Bioassay	Mouse
B Wang, Y Guo, X Chen, C Zeng, Q Hu, W Yin, W Li, H Xie, B Zhang, X Huang, F Yu Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2 Int J Nanomedicine, 2018-11-12;13(0):7395-7408. 2018-11-12 [PMID: 30519022] (Bioassay, Human)	Bioassay	Human
SK Martin, S Fitter, N El Khawank, RH Grose, CR Walkley, LE Purton, MA Ruegg, MN Hall, S Gronthos, ACW Zannettino mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis Sci Rep, 2018-09-28;8(1):14501. 2018-09-28 [PMID: 30266921] (Bioassay, Mouse)	Bioassay	Mouse
V Andreani, S Ramamoorth, A Pandey, E Lupar, SL Nutt, T Lämmermann, R Grosschedl Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and ?1-integrin function Proc. Natl. Acad. Sci. U.S.A., 2018-09-26;0(0):. 2018-09-26 [PMID: 30257949] (Bioassay, Mouse)	Bioassay	Mouse
SJ Keppler, M Burbage, F Gasparrini, L Hartjes, S Aggarwal, MJ Massaad, RS Geha, A Bruckbauer, FD Batista The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses Cell Rep, 2018-07-17;24(3):619-629. 2018-07-17 [PMID: 30021160] (Bioassay, Mouse)	Bioassay	Mouse
Y Duan, E Beli, S Li Calzi, JL Quigley, RC Miller, L Moldovan, D Feng, TE Salazar, S Hazra, J Al-Sabah, KV Chalam, T Le Phuong, M Meroueh, TA Markel, MC Murray, RJ Vyas, ME Boulton, P Parsons-Wi, GY Oudit, AG Obukhov, MB Grant Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction Stem Cells, 2018-07-15;0(0):. 2018-07-15 [PMID: 29761600] (Bioassay, Mouse)	Bioassay	Mouse
N Salazar, JC Carlson, K Huang, Y Zheng, C Oderup, J Gross, AD Jang, TM Burke, S Lewén, A Scholz, S Huang, L Nease, J Kosek, M Mittelbron, EC Butcher, H Tu, BA Zabel A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models Mol. Ther., 2018-03-06;0(0):. 2018-03-06 [PMID: 29606504] (Bioassay)	Bioassay
J Shin, A Fukuhara, T Onodera, S Kita, C Yokoyama, M Otsuki, I Shimomura SDF-1 is an Autocrine Insulin-Desensitizing Factor in Adipocytes Diabetes, 2018-03-26;0(0):. 2018-03-26 [PMID: 29581126] (Cell Culture, Mouse)	Cell Culture	Mouse
H Sun, F Lagarrigue, AR Gingras, Z Fan, K Ley, MH Ginsberg Transmission of integrin ?7 transmembrane domain topology enables gut lymphoid tissue development J. Cell Biol., 2018-03-13;0(0):. 2018-03-13 [PMID: 29535192] (Bioassay, Mouse)	Bioassay	Mouse
M Burbage, SJ Keppler, B Montaner, PK Mattila, FD Batista The Small Rho GTPase TC10 Modulates B Cell Immune Responses J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747344] (Bioassay, Mouse)	Bioassay	Mouse
XW Chen, TJ Yu, J Zhang, Y Li, HL Chen, GF Yang, W Yu, YZ Liu, XX Liu, CF Duan, HL Tang, M Qiu, CL Wang, H Zheng, J Yue, AM Guo, J Yang CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis Oncogene, 2017-05-08;0(0):. 2017-05-08 [PMID: 28481877] (Bioassay, Mouse)	Bioassay	Mouse
M Losada-Bar, A Umaña-Pére, S Cuervo-Esc, LR Berbert, R Porrozzi, FN Morgado, DA Mendes-da-, W Savino, M Sánchez-Gó, P Cuervo Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum Sci Rep, 2017-04-11;7(0):45991. 2017-04-11 [PMID: 28397794] (Bioassay, Mouse)	Bioassay	Mouse
S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 2017-04-10;14(5):531-538. 2017-04-10 [PMID: 28394335] (Bioassay, Mouse)	Bioassay	Mouse
K Choi, K Komurov, JS Fletcher, E Jousma, JA Cancelas, J Wu, N Ratner An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system Sci Rep, 2017-03-03;7(0):43315. 2017-03-03 [PMID: 28256556] (Bioassay, Mouse)	Bioassay	Mouse
IY Hwang, C Park, K Harrison, JH Kehrl Normal Thymocyte Egress, T Cell Trafficking, and CD4(+) T Cell Homeostasis Require Interactions between RGS Proteins and G?i2 J. Immunol, 2017-02-24;0(0):. 2017-02-24 [PMID: 28235863] (Bioassay, Mouse)	Bioassay	Mouse
Christina Schreck Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells J. Exp. Med, 2016-12-20;0(0):. 2016-12-20 [PMID: 27998927] (Bioassay, Mouse)	Bioassay	Mouse
Valentina Cecchinato Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization J. Immunol, 2016-11-28;0(0):. 2016-11-28 [PMID: 27895171] (Bioassay, Mouse)	Bioassay	Mouse
Simon X Liang Proliferation, differentiation and migration of SCA1(-)/CD31(-) cardiac side population cells in vitro and in vivo Int. J. Cardiol., 2016-11-09;0(0):. 2016-11-09 [PMID: 27847151] (Bioassay, Mouse)	Bioassay	Mouse
SDF-1?-induced dual pairs of E-selectin/ligand mediate endothelial progenitor cell homing to critical ischemia Sci Rep, 2016-10-07;6(0):34416. 2016-10-07 [PMID: 27713493] (In Vivo, Mouse)	In Vivo	Mouse
Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization Cell Rep, 2016-09-27;17(1):193-205. 2016-09-27 [PMID: 27681431] (Bioassay, Mouse)	Bioassay	Mouse
ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens J Leukoc Biol, 2016-09-07;0(0):. 2016-09-07 [PMID: 27605210] (Bioassay, Human)	Bioassay	Human
LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells Nat Commun, 2016-09-06;7(0):12719. 2016-09-06 [PMID: 27596364] (In Vivo, Mouse)	In Vivo	Mouse
Proplatelet formation is selectively inhibited by collagen type I via Syk-independent GPVI signaling J Cell Sci, 2016-08-05;0(0):. 2016-08-05 [PMID: 27505889] (Bioassay, Mouse)	Bioassay	Mouse
Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein Sci Rep, 2016-06-07;6(0):27054. 2016-06-07 [PMID: 27270970] (Bioassay, Mouse)	Bioassay	Mouse
S Velasquez, S Malik, SE Lutz, E Scemes, EA Eugenin Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+ T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis J Immunol, 2016-04-13;0(0):. 2016-04-13 [PMID: 27076682] (Bioassay, Mouse)	Bioassay	Mouse
SA Geherin, D Gómez, RA Glabman, G Ruthel, A Hamann, GF Debes IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require ?4?1 Integrin To Migrate between the Peritoneum and Inflamed Skin J. Immunol, 2016-02-05;196(6):2514-25. 2016-02-05 [PMID: 26851219] (Bioassay, Mouse)	Bioassay	Mouse
Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK. PLoS ONE, 2015-04-24;10(4):e0125340. 2015-04-24 [PMID: 25909640] (Bioassay, Mouse)	Bioassay	Mouse
Cheyuo C, Aziz M, Yang W, Jacob A, Zhou M, Wang P Milk fat globule-EGF factor VIII attenuates CNS injury by promoting neural stem cell proliferation and migration after cerebral ischemia. PLoS ONE, 2015-04-13;10(4):e0122833. 2015-04-13 [PMID: 25867181] (Bioassay, Mouse)	Bioassay	Mouse
Wang W, Yu S, Zimmerman G, Wang Y, Myers J, Yu V, Huang D, Huang X, Shim J, Huang Y, Xin W, Qiao P, Yan M, Xin W, Scadden D, Stanley P, Lowe J, Huang A, Siebel C, Zhou L Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention. Stem Cells, 2015-05-13;33(7):2280-93. 2015-05-13 [PMID: 25851125] (Bioassay, Mouse)	Bioassay	Mouse
Chen Q, Zhang M, Li Y, Xu D, Wang Y, Song A, Zhu B, Huang Y, Zheng J CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4. Stem Cells, 2015-05-13;33(8):2574-85. 2015-05-13 [PMID: 25833331] (Bioassay, Mouse)	Bioassay	Mouse
Zychowska M, Rojewska E, Pilat D, Mika J The role of some chemokines from the CXC subfamily in a mouse model of diabetic neuropathy. J Diabetes Res, 2015-02-19;2015(0):750182. 2015-02-19 [PMID: 25789329] (Mouse)		Mouse
Arieta Kuksin C, Gonzalez-Perez G, Minter L CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. Blood, 2015-02-03;125(13):2087-94. 2015-02-03 [PMID: 25647836] (Bioassay, Mouse)	Bioassay	Mouse
Hwang I, Park C, Harrison K, Boularan C, Gales C, Kehrl J An essential role for RGS protein/Galphai2 interactions in B lymphocyte-directed cell migration and trafficking. J Immunol, 2015-01-23;194(5):2128-39. 2015-01-23 [PMID: 25617475] (Bioassay, Mouse)	Bioassay	Mouse
Xu X, Gera N, Li H, Yun M, Zhang L, Wang Y, Wang Q, Jin T GPCR-mediated PLCbetagamma/PKCbeta/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Mol Biol Cell, 2015-01-07;26(5):874-86. 2015-01-07 [PMID: 25568344] (Bioassay, Mouse)	Bioassay	Mouse
Graham K, Zhang J, Lewen S, Burke T, Dang T, Zoudilova M, Sobel R, Butcher E, Zabel B A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS ONE, 2014-12-01;9(12):e112925. 2014-12-01 [PMID: 25437209] (Bioassay, Mouse)	Bioassay	Mouse
Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K Control of lymphocyte egress from lymph nodes through beta2-adrenergic receptors. J Exp Med, 2014-11-24;211(13):2583-98. 2014-11-24 [PMID: 25422496] (Bioassay, Mouse)	Bioassay	Mouse
Beck T, Gomes A, Cyster J, Pereira J CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. J Exp Med, 2014-11-17;211(13):2567-81. 2014-11-17 [PMID: 25403444] (Bioassay, Mouse)	Bioassay	Mouse
Wang Z, Wang Y, Wang Z, Gutkind J, Wang Z, Wang F, Lu J, Niu G, Teng G, Chen X Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury. Stem Cells, 2015-02-01;33(2):456-67. 2015-02-01 [PMID: 25346537] (Bioassay, Mouse)	Bioassay	Mouse
Scherz-Shouval R, Santagata S, Mendillo M, Sholl L, Ben-Aharon I, Beck A, Dias-Santagata D, Koeva M, Stemmer S, Whitesell L, Lindquist S The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell, 2014-07-31;158(3):564-78. 2014-07-31 [PMID: 25083868] (Bioassay, Human)	Bioassay	Human
Menichella D, Abdelhak B, Ren D, Shum A, Frietag C, Miller R CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy. Mol Pain, 2014-06-25;10(0):42. 2014-06-25 [PMID: 24961298] (Bioassay, Mouse)	Bioassay	Mouse
Jin , Qiming, Giannobile , William SDF-1 enhances wound healing of critical-sized calvarial defects beyond self-repair capacity. PLoS ONE, 2014-05-06;9(5):e97035. 2014-05-06 [PMID: 24800841] (Bioassay, Mouse)	Bioassay	Mouse
Geherin , Skye A, Wilson , R Paul, Jennrich , Silke, Debes , Gudrun F CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph. PLoS ONE, 2014-04-21;9(4):e95626. 2014-04-21 [PMID: 24752354] (Bioassay, Mouse, Ovine)	Bioassay	Mouse, Ovine
Januszyk M, Sorkin M, Glotzbach J, Vial I, Maan Z, Rennert R, Duscher D, Thangarajah H, Longaker M, Butte A, Gurtner G Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations. Diabetes, 2014-04-16;63(9):3047-56. 2014-04-16 [PMID: 24740572] (Bioassay, Mouse)	Bioassay	Mouse
Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saitoh K, Yoshimura A, Matsuda T, Kanakura Y Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis. Eur J Immunol, 2014-04-15;44(6):1791-801. 2014-04-15 [PMID: 24733425] (Bioassay, Mouse)	Bioassay	Mouse
Roy , Lopamudr, Sahraei , Mahnaz, Schettini , Jorge L, Gruber , Helen E, Besmer , Dahlia M, Mukherjee , Pinku Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches. BMC Cancer, 2014-03-27;14(0):225. 2014-03-27 [PMID: 24674692] (Bioassay, Mouse)	Bioassay	Mouse
Korthals M, Schilling K, Reichardt P, Mamula D, Schluter T, Steiner M, Langnase K, Thomas U, Gundelfinger E, Premont R, Tedford K, Fischer K alphaPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. J Immunol, 2014-03-03;192(7):3228-38. 2014-03-03 [PMID: 24591366] (Bioassay, Mouse)	Bioassay	Mouse
Bosticardo , Marita, Musio , Silvia, Fontana , Elena, Angiari , Stefano, Draghici , Elena, Constantin , Gabriela, Poliani , Pietro L, Pedotti , Rosetta, Villa , Anna Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein. PLoS ONE, 2014-01-23;9(1):e86942. 2014-01-23 [PMID: 24466296] (Bioassay, Mouse)	Bioassay	Mouse
Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing. Stem Cells, 2014-05-01;32(5):1347-60. 2014-05-01 [PMID: 24446236] (Bioassay, Mouse)	Bioassay	Mouse
Nomachi , Akira, Yoshinaga , Masanori, Liu , Jaron, Kanchanawong , Pakorn, Tohyama , Kiyoshi, Thumkeo , Dean, Watanabe , Takeshi, Narumiya , Shuh, Hirata , Takako Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE, 2013-12-16;8(12):e82590. 2013-12-16 [PMID: 24358210] (Bioassay, Mouse)	Bioassay	Mouse
Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization. PLoS ONE, 2013-11-18;8(11):e80500. 2013-11-18 [PMID: 24260404] (Bioassay, Mouse)	Bioassay	Mouse
Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaor-Kondo A, Maekawa T CCAAT/enhancer-binding protein beta expressed by bone marrow mesenchymal stromal cells regulates early B-cell lymphopoiesis. Stem Cells, 2014-03-01;32(3):730-40. 2014-03-01 [PMID: 24115241] (Bioassay, Mouse)	Bioassay	Mouse
Donnelly J, Chawla A, Houghton J, Zavros Y Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. PLoS ONE, 2013-09-19;8(9):e75225. 2013-09-19 [PMID: 24069395] (Bioassay, Mouse)	Bioassay	Mouse
Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol, 2013-04-15;190(10):5329-36. 2013-04-15 [PMID: 23589623] (ELISA (Capture), Mouse)	ELISA (Capture)	Mouse
Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PLoS ONE, 2013-04-02;8(4):e60226. 2013-04-02 [PMID: 23565202] (Bioassay, Mouse)	Bioassay	Mouse
Hwang I, Hwang K, Park C, Harrison K, Kehrl J Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS ONE, 2013-03-22;8(3):e60139. 2013-03-22 [PMID: 23533672] (Bioassay, Mouse)	Bioassay	Mouse
Lacotte S, Decossas M, Le Coz C, Brun S, Muller S, Dumortier H Early differentiated CD138(high) MHCII+ IgG+ plasma cells express CXCR3 and localize into inflamed kidneys of lupus mice. PLoS ONE, 2013-03-08;8(3):e58140. 2013-03-08 [PMID: 23520491] (Bioassay, Mouse)	Bioassay	Mouse
Kohler T, Reizis B, Johnson RS, Weighardt H, Forster I Influence of hypoxia-inducible factor 1-alpha on dendritic cell differentiation and migration. Eur. J. Immunol., 2012-05-01;42(5):1226-36. 2012-05-01 [PMID: 22539295] (Bioassay, Mouse)	Bioassay	Mouse
Ippagunta SK, Malireddi RK, Shaw PJ The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat. Immunol., 2011-09-04;12(10):1010-6. 2011-09-04 [PMID: 21892172] (Bioassay, Mouse)	Bioassay	Mouse
Cha HR, Ko HJ, Kim ED Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control. J. Immunol., 2011-08-10;187(6):3044-52. 2011-08-10 [PMID: 21832166] (Bioassay, Mouse)	Bioassay	Mouse
Kollmar O, Rupertus K, Scheuer C, Nickels RM, Haberl GC, Tilton B, Menger MD, Schilling MK CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. Int. J. Cancer, 2010-03-15;126(6):1302-15. 2010-03-15 [PMID: 19821487] (Bioassay, Mouse)	Bioassay	Mouse
Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells. J. Exp. Med., 2008-10-13;205(11):2643-55. 2008-10-13 [PMID: 18852294] (Bioassay, Mouse)	Bioassay	Mouse
Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin QD CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice. Fertil. Steril., 2008-04-02;91(6):2687-96. 2008-04-02 [PMID: 18384776] (Bioassay, Mouse)	Bioassay	Mouse
Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J. Immunol., 2007-06-15;178(12):8148-57. 2007-06-15 [PMID: 17548653] (Bioassay, Mouse)	Bioassay	Mouse
Bhangoo SK, Ren D, Miller RJ, Chan DM, Ripsch MS, Weiss C, McGinnis C, White FA CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. Brain Behav. Immun., 2007-02-09;21(5):581-91. 2007-02-09 [PMID: 17292584] (Bioassay, Rat)	Bioassay	Rat
Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y The role of CCL21 in recruitment of T-precursor cells to fetal thymi. Blood, 2004-09-09;105(1):31-9. 2004-09-09 [PMID: 15358618] (Bioassay, Mouse)	Bioassay	Mouse
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Gene Symbol	Cxcl12
Uniprot	P40224()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

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