Recombinant Human CXCL1/GRO alpha Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CXCL1, also known as KC, GRO alpha , and CINC-1, is an approximately 8 kDa proinflammatory chemokine that plays a key role in neutrophil migration and activation (1). Mature human CXCL1 shares 64% and 67% aa sequence identity with mouse and rat CXCL1, respectively (2). It is produced by many cell types in inflammatory sites and during chronic inflammatory diseases (1). CXCL1 can associate into bioactive dimers and primarily signals through CXCR2/IL-8 RB but can also bind with lower affinity to CXCR2/IL-8 RA (3-5). It induces neutrophil migration, extravasation, respiratory burst, and degranulation and also induces T cells to produce proinflammatory IL-17 (4, 6, 7). CXCL1 additionally binds to Syndecan-1 on epithelial cells which acts as a sink for CXCL1 activity until Syndecan-1 cleavage by MMP-7 (8). CXCL1 is up-regulated in spinal cord astrocytes by inflammatory stimuli or tumor cell injection, and it exacerbates pain sensation by potentiating excitatory NMDA neurotransmission (9, 10). In the circulatory system, CXCL1 interacts with CXCR2 on endothelial cells to promote lymphatic tube formation and angiogenesis (11, 12). It promotes the hypertrophic differentiation of chondrocytes resulting in cartilage matrix deposition, calcification, and remodeling (13). It interacts with both CXCR1 and CXCR2 on adipose stromal cells and promotes their recruitment to prostate tumors in obese patients (14). It also binds CXCR2 on ovarian cancer cells, leading to cleavage of cell surface HB-EGF, transactivation of EGF R, and cell proliferation (15).

We have publications tested in 3 confirmed species: Human, Mouse, Virus.

We have publications tested in 7 applications: Binding Assay, Bioassay, Cell Culture, ELISA (Standard), ELISA Developmet, In Vivo, Stimulation.

Showing Publications 1 - 10 of 29. Show All 29 Publications. Collapse Publications.

Publications using 275-GR/CF	Applications	Species
Y Fukawa, K Kayamori, M Tsuchiya, T Ikeda IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma International Journal of Molecular Sciences, 2022-12-30;24(1):. 2022-12-30 [PMID: 36614130] (Cell Culture, Mouse)	Cell Culture	Mouse
S Gnosa, L Puig-Blasc, KB Piotrowski, ML Freiberg, S Savickas, DH Madsen, U Auf dem Ke, P Kronqvist, M Kveiborg ADAM17-mediated EGFR ligand shedding directs macrophage promoted cancer cell invasion JCI Insight, 2022-09-22;0(0):. 2022-09-22 [PMID: 35998057] (Stimulation, Human)	Stimulation	Human
A Conod, M Silvano, A Ruiz I Alt On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm Cell Reports, 2022-03-08;38(10):110490. 2022-03-08 [PMID: 35263600] (Bioassay, Human)	Bioassay	Human
R Roy, J Zayas, SK Singh, K Delgado, SJ Wood, MF Mohamed, DM Frausto, YA Albalawi, TP Price, R Estupinian, EF Giurini, TM Kuzel, A Zloza, J Reiser, SH Shafikhani Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound Elife, 2022-02-03;11(0):. 2022-02-03 [PMID: 35112667] (Bioassay, Human)	Bioassay	Human
JH Kwon, M Kim, S Um, HJ Lee, YK Bae, SJ Choi, HH Hwang, W Oh, HJ Jin Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling Cells, 2021-01-03;10(1):. 2021-01-03 [PMID: 33401590] (Bioassay, Human)	Bioassay	Human
L Bornemann, M Schuster, S Schmitz, C Sobczak, C Bessen, SF Merz, KH Jöckel, T Haverkamp, M Gunzer, JR Göthert Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib BMC Cancer, 2020-07-13;20(1):650. 2020-07-13 [PMID: 32660441] (Bioassay, Human)	Bioassay	Human
L Björkman, K Christenso, L Davidsson, J Mårtensson, F Amirbeagi, A Welin, H Forsman, A Karlsson, C Dahlgren, J Bylund Neutrophil recruitment to inflamed joints can occur without cellular priming J. Leukoc. Biol., 2018-12-20;0(0):. 2018-12-20 [PMID: 30570778] (Bioassay, Human)	Bioassay	Human
M Werner-Kle, S Scheitler, M Hoffmann, I Hodak, K Dietz, P Lehnert, V Naimer, B Polzer, S Treitschke, C Werno, A Markiewicz, K Weidele, Z Czyz, U Hohenleutn, C Hafner, S Haferkamp, M Berneburg, P Rümmele, A Ulmer, CA Klein Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma Nat Commun, 2018-02-09;9(1):595. 2018-02-09 [PMID: 29426936] (Bioassay, Human)	Bioassay	Human
EK Kim, S Moon, DK Kim, X Zhang, J Kim CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma PLoS ONE, 2018-01-23;13(1):e0188847. 2018-01-23 [PMID: 29360827] (Bioassay, Human)	Bioassay	Human
B Schludi, ASM Moin, C Montemurro, T Gurlo, AV Matveyenko, D Kirakossia, DW Dawson, SM Dry, PC Butler, AE Butler Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes JCI Insight, 2017-07-06;2(13):. 2017-07-06 [PMID: 28679961] (Bioassay, Human)	Bioassay	Human
Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases Cell Death Dis, 2016-12-29;7(12):e2565. 2016-12-29 [PMID: 28032864] (Bioassay, Human)	Bioassay	Human
Early dissemination seeds metastasis in breast cancer Nature, 2016-12-14;0(0):. 2016-12-14 [PMID: 27974799] (Bioassay, Human)	Bioassay	Human
Wang H, Hong L, Huang J, Jiang Q, Tao R, Tan C, Lu N, Wang C, Ahmed M, Lu Y, Liu Z, Shi W, Lai E, Wilcox C, Han F P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res, 2015-05-22;25(6):674-90. 2015-05-22 [PMID: 25998681] (Bioassay, Mouse)	Bioassay	Mouse
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE, 2015-03-18;10(3):e0119415. 2015-03-18 [PMID: 25785838] (Bioassay, Human)	Bioassay	Human
Jung J, Lee S, Kim J, Lee S, Sung H, An J, Park Y, Kim B CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells. Stem Cells Dev, 2014-12-23;24(8):948-61. 2014-12-23 [PMID: 25390768] (Bioassay, Human)	Bioassay	Human
Anderson J, Titz B, Akiyama R, Komisopoulou E, Park A, Tap W, Graeber T, Denny C Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol Cancer Res, 2014-08-04;12(12):1740-54. 2014-08-04 [PMID: 25092916] (Bioassay, Human)	Bioassay	Human
Dong Y, Kabir S, Lee E, Son D CXCR2-driven ovarian cancer progression involves upregulation of proinflammatory chemokines by potentiating NF-kappaB activation via EGFR-transactivated Akt signaling. PLoS ONE, 2013-12-20;8(12):e83789. 2013-12-20 [PMID: 24376747] (Bioassay, Human)	Bioassay	Human
Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, Insall R, Stockley R, Lord J Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood, 2013-11-04;123(2):239-48. 2013-11-04 [PMID: 24191150] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation. Eur. J. Haematol., 2009-11-17;84(3):239-51. 2009-11-17 [PMID: 19922462] (Bioassay, Human)	Bioassay	Human
Wu FX, Wang Q, Zhang ZM, Huang S, Yuan WP, Liu JY, Ban KC, Zhao YN Identifying serological biomarkers of hepatocellular carcinoma using surface-enhanced laser desorption/ionization-time-of-flight mass spectroscopy. Cancer Lett., 2009-03-05;279(2):163-70. 2009-03-05 [PMID: 19268439] (ELISA Developmet, Human)	ELISA Developmet	Human
Begley LA, Kasina S, Macdonald J, Macoska JA The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy. Cytokine, 2008-06-24;43(2):194-9. 2008-06-24 [PMID: 18572414] (Bioassay, Human)	Bioassay	Human
Yang HT, Cohen P, Rousseau S IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. Cell. Signal., 2007-11-07;20(2):375-80. 2007-11-07 [PMID: 18065201] (Bioassay, Human)	Bioassay	Human
Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, Yamada H, Huh NH S100A11, an dual mediator for growth regulation of human keratinocytes. Mol. Biol. Cell, 2007-10-31;19(1):78-85. 2007-10-31 [PMID: 17978094] (Bioassay, Human)	Bioassay	Human
Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O Novel antiviral activity of chemokines. Virology, 2006-04-17;350(2):484-92. 2006-04-17 [PMID: 16603217] (Binding Assay, Bioassay, Virus)	Binding Assay, Bioassay	Virus
Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp. Cell Res., 2006-04-04;312(10):1909-23. 2006-04-04 [PMID: 16600214] (Bioassay, Human)	Bioassay	Human
Mihara K, Smit MJ, Krajnc-Franken M, Gossen J, Rooseboom M, Dokter W Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur. J. Immunol., 2005-09-01;35(9):2573-82. 2005-09-01 [PMID: 16094689] (In Vivo, Mouse)	In Vivo	Mouse
Traves SL, Smith SJ, Barnes PJ, Donnelly LE Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. J. Leukoc. Biol., 2004-05-20;76(2):441-50. 2004-05-20 [PMID: 15155777] (Bioassay, Human)	Bioassay	Human
Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J. Immunol., 2002-12-01;169(11):6515-21. 2002-12-01 [PMID: 12444162] (ELISA (Standard))	ELISA (Standard)
Show All 29 Publications. Collapse Publications.

Array 275-GR/CF

• CXCL1/GRO alpha/KC/CINC-1 Antibodies
• CXCL1/GRO alpha/KC/CINC-1 ELISA Kit
• CXCL1/GRO alpha/KC/CINC-1 Proteins
• CXCL1/GRO alpha/KC/CINC-1 Proteins and Enzymes
• CXCL1/GRO alpha/KC/CINC-1 ELISAs