Recombinant Human C1qR1/CD93 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

C1q  R1, also known as CD93 and C1q Rp, is an approximately 125 kDa transmembrane glycoprotein that is involved in various aspects of inflammatory reactions (1). Mature human CD93 consists of a 557 amino acid (aa) extracellular domain (ECD) with one C‑type lectin domain, four tandem EGF‑like domains, and a mucin‑like domain, followed by a 21 aa transmembrane segment and a 51 aa cytoplasmic domain (2, 3). Within the ECD, human CD93 shares 65% aa sequence identity with mouse and rat CD93. It is distinct from the 60 kDa Calreticulin which is likewise known as C1q  R1 (4, 5). Unlike Calreticulin, and despite its name, C1q  R1/CD93 does not appear to bind the complement protein C1q (3, 5). CD93 is expressed by vascular endothelial cells (5) and by a variety of hematopoietic cells (3‑9). Various sized fragments of soluble CD93 (50‑75 kDa) can be shed from monocytes, neutrophils, and vascular endothelial cells following inflammatory stimulation, leaving a residual stub in the membrane (11‑13). Cross‑linking of cell surface CD93 enhances phagocytosis by monocytes and enhances the uptake of apoptotic cells in vivo (10, 15). Soluble CD93 promotes the differentiation of monocytes to macrophages, phagocytosis of apoptotic cells, and inflammatory responsiveness to multiple TLR ligands (12, 14). It is required for plasma cell longevity in the bone marrow and for the resulting extended humoral response (9).

Array 2379-CD

• C1qR1/CD93 Antibodies
• C1qR1/CD93 Antibody Pairs
• C1qR1/CD93 ELISA Kits
• C1qR1/CD93 Lysate
• C1qR1/CD93 Proteins
• C1qR1/CD93 ELISAs
• C1qR1/CD93 Proteins and Enzymes