PGD2 Synthase/PTGDS Antibody [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Prostaglandin D Synthase/Lipocalin (L-PGDS) is a brain-derived protein found most abundantly in CSF and it induces neuronal cell protection and neuronal cell loss, depending on the receptor pathway it signals to the target cells. L-PGDS is found secreted as well as localized to RER, nuclear membrane, Golgi apparatus, perinuclear cytoplasm etc and has been detected in arachnoid and menigioma cells, arachnoid trabecular cells, meningeal macrophages and perivascular microglial cells, oligodendrocytes as well as RPE cells. L-PGDS catalyzes the metabolic transformation of PGH2 to PGD2, a prostaglandin implicated in smooth muscle contraction/relaxation and a platelet aggregation inhibitor. It is implicated in several CNS functions including sedation, NREM sleep and PGE2-induced allodynia, and plays anti-apoptotic role in oligodendrocytes. L-PGDS can bind to small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. L-PGDS has also been suggested to play role in development and maintenance of blood-brain, blood-retina, blood-aqueous humor and blood-testis barriers.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB110-59909V

• PGD2 Synthase/PTGDS Antibodies
• PGD2 Synthase/PTGDS ELISA Kits
• PGD2 Synthase/PTGDS Lysate
• PGD2 Synthase/PTGDS Proteins