PDE6 beta Antibody

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Monkey.

We have publications tested in 1 application: IHC-Fr.

Showing Publications 1 - 2 of 2.

Publications using NB120-5663	Applications	Species
Yamasaki S, Tu H, Matsuyama T et al. A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation iScience 2022-01-01 [PMID: 35024589] (IHC-Fr, Monkey)	IHC-Fr	Monkey
Dong H, Claffey KP, Brocke S, Epstein PM. Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells. Springerplus 2013-01-01 [PMID: 24683528] (Human)		Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Freya Mowat	IHC-Fr	Other	03/24/2014	View Summary Application Immunohistochemistry-Frozen Sample Tested Canine Retina Species Other

Array NB120-5663

• PDE6 beta Antibodies
• PDE6 beta Lysate
• PDE6 beta Proteins