NRL Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

NRL is a 30 kDa nuclear transcription factor that belongs to the Maf subfamily within the bZIP (basic motif-leucine zipper) transcription factor family. It contains an N‑terminal transcriptional activation domain and a C-terminal DNA-binding bZIP domain that is also involved in homo- or heterodimerization. NRL regulates the expression of rod-specific genes and is expressed specifically in rod photoreceptors. NRL is phosphorylated at multiple sites, which likely regulates its activity. The amino acid sequence of human NRL is 92%, 94%, 90% and 90% identical to that of bovine, canine, rat and mouse NRL, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Xenograft.

We have publications tested in 5 applications: Functional Assay, ICC, IHC, IHC-Fr, Immunohistochemistry.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using AF2945	Applications	Species
Corso-Díaz, X;Liang, X;Preston, K;Tegshee, B;English, MA;Nellissery, J;Yadav, SP;Marchal, C;Swaroop, A; Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors bioRxiv : the preprint server for biology 2024-09-19 [PMID: 39345562] (Immunohistochemistry, Functional Assay, Mouse)	Immunohistochemistry, Functional Assay	Mouse
LR Bohrer, NE Stone, NK Mullin, AP Voigt, KR Anfinson, JL Fick, V Luangphakd, B Hittle, K Powell, GF Muschler, RF Mullins, EM Stone, BA Tucker Automating iPSC generation to enable autologous photoreceptor cell replacement therapy Journal of Translational Medicine, 2023-02-28;21(1):161. 2023-02-28 [PMID: 36855199] (IHC, Human)	IHC	Human
Nguyet Le, Haley Appel, Nicole Pannullo, Thanh Hoang, Seth Blackshaw Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina Frontiers in Cell and Developmental Biology 2022-09-19 [PMID: 36200040]
IC Han, LR Bohrer, KN Gibson-Cor, LA Wiley, A Shrestha, BE Harman, C Jiao, EH Sohn, R Wendland, BN Allen, KS Worthingto, RF Mullins, EM Stone, BA Tucker Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats Cell Transplantation, 2022-01-01;31(0):9636897221104. 2022-01-01 [PMID: 35758274] (ICC, Human)	ICC	Human
Yuki Otsuka, Keiko Imamura, Akio Oishi, Takayuki Kondo, Mika Suga, Yuichiro Yada et al. One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors iScience 2022-04-15 [PMID: 35330684]
S Yamasaki, A Kuwahara, A Kishino, T Kimura, M Takahashi, M Mandai Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture Regenerative Therapy, 2022-01-01;19(0):24-34. 2022-01-01 [PMID: 35059477] (IHC, Human)	IHC	Human
Afanasyeva TAV, Corral-Serrano JC, Garanto A et al. A look into retinal organoids: methods, analytical techniques, and applications Cellular and Molecular Life Sciences 2021-10-01 [PMID: 34420069]
Cowan CS, Renner M, De Gennaro M et al. Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution Cell 9/17/2020 [PMID: 32946783]
Lu Y, Shiau F, Yi W et al. Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development Dev. Cell 5/18/2020 [PMID: 32386599]
Mei-Ling G, Xin-Lan L, Fang H et al. Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa. Front Cell Dev Biol. 2020-03-06 [PMID: 32211407]
A Kuwahara, S Yamasaki, M Mandai, K Watari, K Matsushita, M Fujiwara, Y Hori, Y Hiramine, D Nukaya, M Iwata, A Kishino, M Takahashi, Y Sasai, T Kimura Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue Sci Rep, 2019-12-12;9(1):18936. 2019-12-12 [PMID: 31831759] (IHC-Fr, Human, Xenograft)	IHC-Fr	Human, Xenograft
Alexandra Garancher, Charles Y. Lin, Morgane Morabito, Wilfrid Richer, Nathalie Rocques, Magalie Larcher et al. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma Cancer Cell 2018-03-12 [PMID: 29533784]
Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, Duran Y, Blackford S, Abelleira-Hervas L, Sampson R, Shum I, Branch M, Gardner P, Sowden J, Bainbridge J, Smith A, West E, Pearson R, Ali R Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors. Stem Cell Reports, 2017-08-24;9(3):820-837. 2017-08-24 [PMID: 28844659] (IHC, Human)	IHC	Human
Show All 13 Publications. Collapse Publications.

Array AF2945

• NRL Antibodies
• NRL Lysate