pan Cadherin Antibody

Cadherins are members of a multigene family of single chain glycoprotein receptors mediating Ca++-dependent cell-cell adhesion.1,2,3 The N-terminal part of these molecules is exposed on the external cell surface and contains the putative homophilic binding sites. This is followed by a typical single transmembrane sequence and usually, a cytoplasmic C-terminal tail4 which mediates interaction with the microfilament system through molecules such as catenins, plakoglobin, vinculin, and a-actinin. Cadherins which are primarily located in areas of cell-cell contacts, are involved in selective cell sorting and in the mechanical cytoplasmic response. They are implicated in morphogenetic processes, intercellular signalling and tumor invasiveness and metastasis. Multiple cadherins were characterized from diverse species and tissues including E-Cadherin, N-Cadherin (A-CAM), P-Cadherin, V-Cadherin, R-Cadherin and T-Cadherin. Specific antibodies against a highly conserved sequence from the cytoplasmic C-terminal of N-Cadherin have been prepared.5,6

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC-P, WB.

Showing Publications 1 - 9 of 9.

Publications using NB200-592	Applications	Species
Mareninova OA, Vegh ET, Shalbueva N et al. Dysregulation of mannose-6-phosphate dependent cholesterol homeostasis in acinar cells mediates pancreatitis The Journal of clinical investigation 2021-06-15 [PMID: 34128834] (Mouse)		Mouse
Liu X, Bao X, Hu M et al. Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer Nature 2020-11-11 [PMID: 33177715]
Jacqueline Chevalier, Hao Yin, John-Michael Arpino, Caroline O'Neil, Zengxuan Nong, Kevin J. Gilmore, Jason J. Lee, Emma Prescott, Matthew Hewak, Charles L. Rice, Luc Dubois, Adam H. Power, Douglas W. Hamilton, J. Geoffrey Pickering Obstruction of Small Arterioles in Patients with Critical Limb Ischemia due to Partial Endothelial-to-Mesenchymal Transition iScience 2020-06-06 [PMID: 32629616]
Yu G, Liu Y, Qin J et al. Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Nav1.5 clarify the molecular basis of Brugada syndrome. J. Biol. Chem. 2018-10-03 [PMID: 30282806] (WB, Human)	WB	Human
Cao Y, Slaney CY, Bidwell BN et al. BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity. Cancer Res. 2014-09-15 [PMID: 25224959] (IHC-P, Mouse)	IHC-P	Mouse
Karamchandani J, Wu MY, Das S et al. Highly proliferative sellar chordoma with unusually rapid recurrence Neuropathology 2012-10-22 [PMID: 23082799] (IF/IHC, Human)	IF/IHC	Human
Adams JR, Xu K, Liu JC et al. Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Res. 2011-04-01 [PMID: 21324922] (IHC-P, Mouse)	IHC-P	Mouse
Jiang Z, Deng T, Jones R et al. Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest. 2010-09-01 [PMID: 20679727] (IHC-P, ICC/IF, Mouse)	IHC-P, ICC/IF	Mouse
Karlen A, Karlsson TE, Mattsson A et al. Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci U S A;106(48):20476-81. 2009-12-01 [PMID: 19915139]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Sanghyuk Chung	IHC-P	Mouse	12/20/2016	View Summary Application Immunohistochemistry-Paraffin Sample Tested Mouse cervix Species Mouse Comments Comments antigen retrieval with pepsin treatment

Array NB200-592

• pan Cadherin Antibodies
• pan Cadherin Protein