p19ARF/CDKN2A Antibody (5-C3-1) [HRP]

In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publication 1 - 1 of 1.

Publication using NB200-174H	Applications	Species
Olive V, Sabio E, Bennett MJ et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife 2013-10-15 [PMID: 24137534] (WB, Mouse) Details: Using the HRP conjugated version of NB200-174, catalog number NB200-174H.	WB	Mouse

Array NB200-174H

• p19ARF/CDKN2A Antibodies
• p19ARF/CDKN2A ELISA Kits
• p19ARF/CDKN2A Protein