Orthogonal Strategies: Immunohistochemistry-Paraffin: P-Cadherin Antibody [NBP1-85707] - Analysis in human skin and skeletal muscle tissues. Corresponding CDH3 RNA-seq data are presented for the same tissues.
Western Blot: P-Cadherin Antibody [NBP1-85707] - Analysis in human cell line RT-4.
Immunohistochemistry-Paraffin: P-Cadherin Antibody [NBP1-85707] - Staining of human skin shows moderate membranous positivity in squamous epithelial cells.
Immunohistochemistry-Paraffin: P-Cadherin Antibody [NBP1-85707] - Staining of human colon shows weak membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: P-Cadherin Antibody [NBP1-85707] - Staining of human skeletal muscle shows no membranous positivity in myocytes as expected.
Immunohistochemistry-Paraffin: P-Cadherin Antibody [NBP1-85707] - Staining of human placenta shows moderate membranous positivity in trohoblastic cells.
This antibody was developed against Recombinant Protein corresponding to amino acids: YNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPE
Marker
Intercellular Junctions Marker
Predicted Species
Mouse (90%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CDH3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified
Alternate Names for P-Cadherin Antibody
CAD3
cadherin 3, P-cadherin (placental)
cadherin 3, type 1, P-cadherin (placental)
Cadherin-3
CDH3
CDHP
CDHPcalcium-dependent adhesion protein, placental
HJMD
PCAD
PCadherin
P-Cadherin
PCADP-cadherin
Placental cadherin
Background
The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. R-cadherin (for retinal-cadherin, also designated cadherin-4), which was first identified in the retina of chicken, has been shown to be involved in the development of striated muscle and potentially epithelia in addition to its involvement in retinal development.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for P-Cadherin Antibody (NBP1-85707)(3)
We have publications tested in 2 confirmed species: Human, Rat.
We have publications tested in 3 applications: ICC/IF, IF/IHC, IHC-P.
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ICC/IF
(1)
IF/IHC
(1)
IHC-P
(2)
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Human
(2)
Rat
(1)
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Showing Publications 1 - 3 of 3.
Publications using NBP1-85707
Applications
Species
Bassam AM, Eesa AN et al. Expression of E-Cadherin and P-Cadherin in Breast Carcinoma. Middle-East Journal of Scientific Research. 2015-01-01 (IHC-P, Human)
Fawzy A, Allah S, Salem M, Al Farouk L Immunohistochemical and Histopathological Study of Anaplastic Lymphoma Kinase and Tyrosine-kinase Receptor Expression in Bronchogenic Carcinoma Open Access Macedonian Journal of Medical Sciences 2021-02-18 (IHC-P, Human)
IHC-P
Human
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