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Optineurin Antibody (S01-2C5)

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Western Blot: Optineurin Antibody (S01-2C5) [NBP3-19900] - Western blot detection of Optineurin in Hela, A549, HL-60, U2OS, U87-MG cell lysates using NBP3-19900 (1:1000 diluted). Predicted band size: 66kDa. Observed band size: 75kDa.
Western Blot: Optineurin Antibody (S01-2C5) [NBP3-19900] - Western blot detection of Optineurin in Hela, A549, HL-60, U2OS, U87-MG cell lysates using NBP3-19900 (1:1000 diluted). Predicted band size: 66kDa. Observed ...read more
Immunohistochemistry-Paraffin: Optineurin Antibody (S01-2C5) [NBP3-19900] - Immunohistochemistry of Optineurin in paraffin-embedded Human Cholangiocarcinoma using NBP3-19900 at dilution 1/50
Genetic Strategies: Western blot shows lysates of U2OS and Optineurin knockout U2OS cell line (KO). Nitrocellulose membrane was probed with Optineurin Antibody (Catalog # NBP3-19900) O/N at 4C, followed by ...read more
U2OS lysates were prepared, and immunoprecipitation was performed using 2.0 ug of Optineurin antibody (Catalog # NBP3-19900) pre-coupled to Dynabeads protein A. Samples were washed and processed for Western Blot with ...read more
Genetic Strategies: U2OS WT and Optineurin KO cells were labelled with a green or a far-red fluorescent dye, respectively. Cells were stained with Optineurin antibody and with the corresponding Alexa-fluor 555 ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
S01-2C5
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.3 mg/ml
Validated by:
     

Genetic Strategies

    

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Optineurin Antibody (S01-2C5) Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant protein of human Optineurin (Uniprot # Q96CV9)
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
OPTN
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1/50
  • Immunohistochemistry-Paraffin
  • Western Blot 1/1000
Theoretical MW
75 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium Azide
Concentration
0.3 mg/ml
Purity
Affinity purified

Alternate Names for Optineurin Antibody (S01-2C5)

  • ALS12
  • FIP2
  • FIP2FIP-2
  • GLC1E
  • GLC1Eglaucoma 1, open angle, E (adult-onset)
  • HIP7
  • HIP7ALS12
  • Huntingtin interacting protein L
  • Huntingtin yeast partner L
  • Huntingtin-interacting protein 7
  • Huntingtin-interacting protein L
  • HYPL
  • HYPLHIP-7
  • NEMO-related protein
  • NRP
  • NRPE3-14.7K-interacting protein
  • Optic neuropathy-inducing protein
  • Optineurin
  • OPTN
  • TFIIIA-INTP
  • Transcription factor IIIA-interacting protein
  • transcrption factor IIIA-interacting protein
  • tumor necrosis factor alpha-inducible cellular protein containing leucinezipper domains

Background

Optineurin encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Optineurin
Antibody (S01-2C5)
NBP3-19900
Optineurin Antibody (S01-2C5)
Species: Hu
Applications: WB, IHC

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Bioinformatics

Gene Symbol OPTN