NuMA Antibody

The nuclear mitotic apparatus protein (NuMA) is a critical component of the mitotic spindle that is responsible for organizing minus-ends of microtubules at spindle poles. NUMA is regulated by phosphorylation and associates with dynein and dynactin in its phosphorylated form. Dephosphorylation of NUMA in anaphase results in the release from dynein and dynactin to allow spindle disassembly. NUMA, in association with dynein and dynactin, also interacts with 4.1R in a complex of spindle pole organizing proteins. Other NUMA interacting proteins include GAS41, tankyrase, and Rae1. These interactions indicate a broader role for NUMA function in the nucleus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NB100-74636	Applications	Species
Rodina A, Xu C, Digwal CS et al. Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation Nature communications 2023-06-23 [PMID: 37353488] (WB, Human) Details: 1:1000 dilution	WB	Human
Liang D, Sun Q, Zhu Z et al. Xenotransplantation of Human Spermatogonia Into Various Mouse Recipient Models Frontiers in Cell and Developmental Biology 2022-05-23 [PMID: 35676935]
Serpico AF, Febbraro F, Pisauro C, Grieco D Compartmentalized control of Cdk1 drives mitotic spindle assembly Cell reports 2022-01-25 [PMID: 35081344] (WB, Human)	WB	Human
Yan K, Li L, Wang X et al. The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells J. Cell Biol. 2015-07-20 [PMID: 26195665] (WB, Human)	WB	Human

Array NB100-74636

• NuMA Antibodies
• NuMA Lysate
• NuMA Proteins