Notch-1 Antibody - BSA Free

Notch1 is a single-pass transmembrane protein that serves as the receptor for the Delta1, Jagged1 and Jagged2 ligands. Activation of Notch1 causes the cytoplasmic domain to be cleaved, releasing the notch intracellular domain (NICD) which forms a complex with RBPJ/RBPSUH and subsequently influences transcription of its target genes. Because the majority of Notch1 ligands are transmembrane proteins, Notch1 is primarily triggered by cell-to-cell contact and employs lateral inhibition mechanisms to influence local populations of cells. The Notch1 pathway plays a pivotal role in development, including cell-fate determination, proliferation, and cell contact-dependent signaling. Aberrant activation of the Notch1 pathway has been associated with numerous diseases such as bicuspid aortic valve and cancer-- in particular certain leukemias.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ICC/IF, KD, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-78292	Applications	Species
Canesin G, FeldbrUgge L, Wei G et al. Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells iScience 2022-09-01 [PMID: 36093061]
Minguzzi M, Panichi V, D'Adamo S Et al. Pleiotropic Roles of NOTCH1 Signaling in the Loss of Maturational Arrest of Human Osteoarthritic Chondrocytes International journal of molecular sciences 2021-11-05 [PMID: 34769441] (KD, ICC/IF, Human)	KD, ICC/IF	Human
Kobayashi T, Piao W, Takamura T et al. Enhanced lysosomal degradation maintains the quiescent state of neural stem cells Nat Commun. 2019-11-29 [PMID: 31784517] (WB, Mouse)	WB	Mouse
Zhang B, Elmabsout AA, Khalaf H et al. The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation. BMC Genomics. 2013-11-09 [PMID: 24209892] (WB, Human)	WB	Human
Park S, Kim J, Kim Y. Mulberry leaf extract inhibits cancer cell stemness in neuroblastoma Nutr Cancer 2012-08-01 [PMID: 22860924] (WB, Human)	WB	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Manjinder Cheema	WB	Mouse	02/18/2020	View Summary Application Western Blot Sample Tested Mouse brain,Mouse kidney,mouse liver,Mouse Spleen Species Mouse Lot A-2

Array NBP1-78292

• Notch-1 Antibodies
• Notch-1 ELISA Kits
• Notch-1 Lysate
• Notch-1 Proteins
• Notch-1 Proteins and Enzymes
• Notch-1 ELISA