NHE8 Antibody (7A11)

NHE (Na+/H+ Exchanger) family members are integral membrane proteins which have been identified to play a key role in catalyzing the extrusion of intracellular proton (H+) ions in exchange for extracellular sodium (Na+) ions for regulation of cellular pH as well as transepithelial ion/water transport. NHE8 is a relatively new member of Na+/H+ exchanger family and is a ubiquitously expressed protein with highest levels detected in epithelial cells of the intestine and the kidney as well as in skeletal muscles. Interestingly, the intestinal/renal expression levels of NHE8 are significantly higher than that of NHE2/NHE3 at a young age, suggesting that NHE8 as an important player for sodium absorption during early development. Localized mainly in Golgi apparatus membranes as multi-pass membrane protein, NHE8 is implicated in regulation of pH to eliminate acids generated by active metabolism or to counter adverse environmental conditions. NHE8 is a major proton extruding system driven by the inward sodium ion chemical gradient and has also been proposed to play role in signaling mechanisms also.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 5 of 5.

Publications using NB110-62091	Applications	Species
Kinaneh S, Knany Y, Khoury EE et al. Identification, localization and expression of NHE isoforms in the alveolar epithelial cells PLOS ONE 2021-04-21 [PMID: 33882062]
Baum M, Martin MG, Booth IW, Holmberg C, Twombley K, Zhang Q, Gattineni J, Moe O. Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea. J Pediatr Gastroenterol Nutr;53(5):474-7. 2011-11-01 [PMID: 21666503] (WB, Mouse)	WB	Mouse
Twombley K, Gattineni J, Bobulescu IA, Dwarakanath V, Baum M. Effect of metabolic acidosis on neonatal proximal tubule acidification. Am J Physiol Regul Integr Comp Physiol;299(5):R1360-8. 2010-11-01 [PMID: 20720175] (WB, Rat, Mouse)	WB	Rat, Mouse
Zhang J, Bobulescu IA, Goyal S, Aronson PS, Baum MG, Moe OW. Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells. Am J Physiol Renal Physiol;293(3):F761-6. 2007-09-01 [PMID: 17581925]
Goyal, S et al. Immunolocalization of NHE8 in rat kidney. Am J Physiol Renal Physiol;288(3):F530-8. 2005-03-01 [PMID: 15522984] (WB, ICC/IF, Rat)	WB, ICC/IF	Rat

Array NB110-62091

• NHE8 Antibodies
• NHE8 Lysate