MUC2 Antibody (996/1) - BSA Free

MUC2, also called mucin 2, is a member of the mucin protein family which are heavily glycosylated, high molecular weight proteins that are produced by goblet cells in epithelial tissues including the intestinal and respiratory tract (1). Mucins can form gels and function in lubrication of mucosal surfaces which serve as a protective barrier of the epithelial lining and an innate host defense (1). Mucins are divided into two groups based on whether they are membrane-bound or secreted, where MUC2 belongs to the secretory group (1,2). Secreted mucins have a distinctive composition characterized by a large central exon "mucin domain" containing O-glycosylated tandem repeat regions rich in proline, threonine, and serine residues, non-repetitive domains, and cysteine-rich domains (1,2). The mucin domain is flanked by 5' and 3' D domains, a B-like domain, a C-like domain, and a Ck-domain (1,2). MUC2 was the first secretory mucin identified in humans (3,4). Full-length MUC2 protein is synthesized as 5179 amino acids (aa) in length with a theoretical molecular weight of ~540 kDa (5).

Changes or perturbations to MUC2 expression has been associated with a number of disease pathologies (1-4, 6). Specifically, altered MUC2 composition has been indicated in colorectal cancer, inflammatory bowel diseases (IBD) including ulcerative colitis and Chron's disease, and chronic obstructive pulmonary disease (COPD) (1-4, 6). In general, decreased or reduced MUC2 expression is associated with colorectal cancer disease progression and development of IBD (1-4, 6). Additionally, studies have found that upon intestinal infection due to parasites or bacteria MUC2 expression is increased, as is overall mucus secretion (3, 6).

References

1. Pothuraju, R., Krishn, S. R., Gautam, S. K., Pai, P., Ganguly, K., Chaudhary, S., Rachagani, S., Kaur, S., & Batra, S. K. (2020). Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer. Cancers. https://doi.org/10.3390/cancers12030649

2. Ballester, B., Milara, J., & Cortijo, J. (2019). Mucins as a New Frontier in Pulmonary Fibrosis. Journal of Clinical Medicine. https://doi.org/10.3390/jcm8091447

3. Liu, Y., Yu, X., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020). The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.07.191

4. Allen, A., Hutton, D. A., & Pearson, J. P. (1998). The MUC2 gene product: a human intestinal mucin. The International Journal of Biochemistry & Cell Biology. https://doi.org/10.1016/s1357-2725(98)00028-4

5. Uniprot (Q02817)

6. Kim, Y. S., & Ho, S. B. (2010). Intestinal goblet cells and mucins in health and disease: recent insights and progress. Current Gastroenterology Reports. https://doi.org/10.1007/s11894-010-0131-2

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: FLOW, IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB120-11197	Applications	Species
Xie Z, Li M, Qian M et al. Co-Cultures of Lactobacillus acidophilus and Bacillus subtilis Enhance Mucosal Barrier by Modulating Gut Microbiota-Derived Short-Chain Fatty Acids Nutrients 2022-10-25 [PMID: 36364738] (WB)	WB
Wanner N, Barnhart J, Apostolakis N Et al. Using the Autofluorescence Finder on the Sony ID7000(TM) Spectral Cell Analyzer to Identify and Unmix Multiple Highly Autofluorescent Murine Lung Populations Front Bioeng Biotechnol 2022-04-04 [PMID: 35372303] (FLOW, Mouse) Details: Citation using the Alexa Fluor 532 version of this antibody.	FLOW	Mouse
Bao L, Cui X, Wang X et al. Carbon Nanotubes Promote the Development of Intestinal Organoids through Regulating Extracellular Matrix Viscoelasticity and Intracellular Energy Metabolism ACS Nano 2021-10-26 [PMID: 34622660] Details: Citation using the PE format of this antibody.
Xu P, Xi Y, Zhu J et al. Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis Gastroenterology 2021-04-02 [PMID: 33819483] (IF/IHC, Mouse)	IF/IHC	Mouse
Yang KS, Ciprani D, O'Shea A et al. EXTRACELLULAR VESICLE ANALYSIS ALLOWS FOR IDENTIFICATION OF INVASIVE IPMN Gastroenterology 2020-12-07 [PMID: 33301777] (Human)		Human
Wu H, Chen QY, Wang WZ et al. Compound sophorae decoction enhances intestinal barrier function of dextran sodium sulfate induced colitis via regulating notch signaling pathway in mice Biomed Pharmacother 2020-11-17 [PMID: 33217689] (WB, Mouse)	WB	Mouse
Yu Y, Lu J, Oliphant K et al. Maternal administration of probiotics promotes gut development in mouse offsprings PLoS ONE 2020-08-07 [PMID: 32764797] (Mouse)		Mouse
Talbot S, Doyle B, et al. Vagal sensory neurons drive mucous cell metaplasia. J Allergy Clin Immunol 2020-06-01 [PMID: 31954778] (FLOW, Mouse)	FLOW	Mouse
Li B, Lee C et al. Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair. Sci Rep 2017-11-05 [PMID: 31748698] (IF/IHC, Mouse)	IF/IHC	Mouse
Li B, Lee C, Filler T, Hock A Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair Sci Rep. 2017-05-10 [PMID: 28492284] (IF/IHC, Mouse)	IF/IHC	Mouse
Mishra J, Verma RK, Alpini G et al. Role of janus kinase 3 in mucosal differentiation and predisposition to colitis. J Biol Chem. 2013-11-01 [PMID: 24045942] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Sweta Ghosh	IHC-P	Mouse	05/10/2024	View Summary Application Immunohistochemistry-Paraffin Sample Tested Colon tissue Species Mouse Lot A-8
	3 reviewed by: Verified Customer	IHC-P	Other	03/11/2009	View Summary Application Immunohistochemistry-Paraffin Sample Tested pig lung Species Other Lot 996/1

Array NB120-11197

• MUC2 Antibodies
• MUC2 ELISA Kits